生血宁片结合罗沙司他治疗肾性贫血临床疗效研究  

Clinical Efficacy of Shengxuening Tablet(生血宁片)Combined with Roxastat in Treatment of Renal Anemia

作　　者：刘璐[1] 许岭 王允吉 胡娣娟 胡文晋[1] LIU Lu;XU Ling;WANG Yunji;HU Dijuan;HU Wenjin(The Second Hospital of Nanjing,Nanjing University of Chinese Medicine,Nanjing 210023,Jiangsu,China)

机构地区：[1]南京中医药大学附属南京医院,南京市第二医院,江苏南京210023

出　　处：《中华中医药学刊》2022年第9期247-250,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：江苏省科技计划(BE2016754)。

摘　　要：目的探究生血宁片结合罗沙司他治疗肾性贫血临床疗效及安全性,为肾性贫血患者提供可靠安全治疗方法。方法研究共计纳入99例肾性贫血患者,均由江苏省人民医院二院院区2018年1月—2020年11月收治,采取随机数字表法将纳入患者分成观察组以及对照组,予以对照组患者(50例)罗沙司他胶囊治疗,予以观察组患者(49例)罗沙司他胶囊结合生血宁片治疗,比较两组患者临床疗效、治疗前后贫血指标变化及中医症状(面浮身肿、神疲乏力、面色萎黄、气短懒言、头晕目眩等)积分变化、铁代谢指标变化、肾功能指标及氧化应激指标变化、炎症因子指标变化、不良反应。结果观察组患者治疗总有效率(95.92%,47/49)高于对照组患者(84.00%,42/50)(P<0.05);治疗前,两组患者血细胞比容(Hct)、红细胞计数(RBC)、血红蛋白(Hb)、等贫血指标、面浮身肿、神疲乏力、面色萎黄、气短懒言、头晕目眩等中医症状积分、转铁蛋白(TRF)、转铁蛋白饱和度(TSAT)及血清铁蛋白(SF)等铁代谢指标、尿素氮(BUN)及血肌酐(Scr)、24 h尿蛋白定量(24 hPRO)等肾功能指标、氧化应激指标超氧化物歧化酶(SOD)、C反应蛋白(CRP)等炎症因子水平比较,P>0.05,治疗后各组患者Hct、RBC、Hb、面浮身肿、神疲乏力、面色萎黄、气短懒言、头晕目眩等中医症状积分、TRF、TSAT、SF、BUN、Scr、24 hPRO、SOD、CRP等指标均改善,观察组患者治疗后Hct、RBC、Hb、面浮身肿、神疲乏力、面色萎黄、气短懒言、头晕目眩等中医症状积分、TRF、TSAT、SF、BUN、Scr、24 hPRO、SOD、CRP等指标均优于对照组(P<0.05);观察组(4.08%,2/49)与对照组(4.00%,2/50)不良反应率均较低(P>0.05)。结论生血宁片结合罗沙司他治疗肾性贫血临床疗效,患者贫血症状改善,肾功能恢复良好,不良反应少,安全性高,值得应用。Objective To investigate the elinical fficacey and safety of Shengxuening Tablet(生血宁片)combined with roxas-tat in the treatment of renal anemia,8s0 as to provide a reliable and safe treatment method for patients with renal anemia.Methods The study totally included 99 patients with renal anemia,all treated by The Second Hospital of Jiangsu Provincial Peoples Hospi-tal from Janwary 2018 to November 2020.By laking a random number table method,the patients were divided into the observation group and the control group.The control group's patients(50 cases)were treated with Roxastatin Capsules.The observation group's patients(49 cases)were treated with Roxastatin Capsules combined with Shengxuening Tablet,The elinical ffcacy,changes in anemia indexes,scores changes in TCM symptoms(facial swelling,fatigue,sallow complexion,shortness of breath,lazy speech,dizziness,etc.),changes in iron metabolism indexes,changes in renal function indexes and oxidative stress inde-xes,changes in inflammatory factors indexes,and adverse reactions were compared between the two groups before and afer treat-ment.Results The total effective rate of the observation group(95.92%,47/49)was higher than that of the control group(84.00%,42/50)(P<0.05).Before treatment,the levels of hematocrit(Hct),red blood cells count(RBC),hemoglobin(Hb)and other indicators of anemia,the scores of TCM symptoms(facial swelling,fatigue,sallow complexion,shortness of breath,lazy speech,dizziness,etc.),the levels of transferrin(TRF),,transferrin saturation(TSAT),serum frritin(SF)and other iron metabolism indicators,the levels of urea nitrogen(BUN),blood creatinine(SCR),24 h urinary protein quantification(24 h pro)and other renal function indicators,the levels of oxidative stress indicators,superoxide dismutase(SOD),C-reac-tive protein(CRP)and other inflammatory factors of the two groups were not signifcant(P>0.05).After treatment,the indexes above were improved in each group.After treatment,the levels of HCT,RBC and Hb,the TCM symptom scores(facial swelling,fat

关 键 词：肾性贫血 生血宁片 罗沙司他胶囊 疗效 肾功能 贫血指标 不良反应 

分 类 号：R259.56[医药卫生—中西医结合]