负载miRNA-126的间充质干细胞外泌体在脓毒性休克心功能障碍机制中的研究进展  

Advances in the application of exosomes of mesenchymal stem cells carrying miRNA-126 in septic shock cardiac dysfunction

作　　者：王莉[1,2] 刘春峰 Wang Li;Liu Chunfeng(Department of Pediatrics,Shengjing Hospital of China Medical University,Shenyang 110004,China;NICU,Dalian Municipal Women and Children′s Medical Center(Group),Dalian 116037,China)

机构地区：[1]中国医科大学附属盛京医院儿科,沈阳110004 [2]大连市妇女儿童医疗中心(集团)NICU,116037

出　　处：《中国小儿急救医学》2022年第10期817-822,共6页Chinese Pediatric Emergency Medicine

基　　金：国家自然科学基金(81971810);辽宁省科技重大专项计划(2020JH1/10300001);沈阳市科学技术计划(沈科发2020-30号)。

摘　　要：外泌体在细胞通讯和信息传递之间有着重要的意义。间充质干细胞(MSC)外泌体负载的miRNA-126可以通过调节蛋白表达等途径减轻炎症反应并保护血管内皮, 从而阻断或减轻脓毒症休克心功能障碍, 有望成为脓毒症休克心功能障碍治疗的新途径。Exosomes play important roles in cell communication and information transmission.miRNA-126 carried by mesenchymal stem cells exosomes can reduce inflammatory response and protect vascular endothelium by regulating protein expression,thus blocking or alleviating cardiac dysfunction during septic shock,which is expected to become a new way to treat septic shock cardiac dysfunction.

关 键 词：脓毒症 心功能障碍 外泌体 miRNA-126 

分 类 号：R459.7[医药卫生—急诊医学]