胎儿炎症反应综合征与新生儿临床结局  

Fetal inflammatory response syndrome and neonatal clinical outcomes

作　　者：单莹[1] 富建华[1] Shan Ying;Fu Jianhua(Department of Pediatrics,Shengjing Hospital of China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院儿内科,沈阳110004

出　　处：《中国小儿急救医学》2022年第10期823-827,共5页Chinese Pediatric Emergency Medicine

基　　金：辽宁省科技创新重大专项(2020JH1/10300001)。

摘　　要：胎儿炎症反应综合征(FIRS)是全身炎症反应在胎儿中的状态, 通过感染性和非感染性途径诱发, 以白细胞介素-6为代表的细胞因子水平增加, 绒毛膜羊膜炎和脐带炎为其常见的胎盘病理学改变。FIRS不仅可以导致早产, 还与新生儿期脑损伤、肺损伤、早发型败血症、坏死性小肠结肠炎、心血管系统疾病等多器官系统损伤密切相关。因此, 减少FIRS对新生儿所致的损害, 是产科、儿科医生共同面临的临床问题。Fetal inflammatory response syndrome(FIRS)is a state of systemic inflammatory response in the fetus,induced by infectious and non-infectious pathways,with increased levels of cytokines represented by interleukin-6.Chorioamnionitis and funisitis are common placental pathological changes of FIRS.FIRS can not only lead to premature birth,but also is closely related to multiple organ damage such as brain injury,lung injury,early-onset sepsis,necrotizing enterocolitis,and cardiovascular system diseases during the neonatal period.Therefore,reducing the damage caused by FIRS to neonates is a common clinical problem that obstetricians and pediatricians will face together.

关 键 词：胎儿炎症反应综合征 诊断 临床结局 新生儿 

分 类 号：R722.1[医药卫生—儿科]