2型糖尿病患者脂联素、GA/HbA1c比值与周围神经病变的相关性研究  

Correlation between adiponectin,GA/HbA1c ratio and peripheral neuropathy in patients with type 2 diabetes mellitus

作　　者：赵维丽[1] 徐运强[1] 郑盼盼 刘蓓[1] 杨会芳[1] 王哲[1] 李坤[1] ZHAO Weili;XU Yunqiang;ZHENG Panpan(Department of Clinical Laboratory,The Second Hospital of Shijiazhuang City,Hebei,Shijiazhuang 050051,China)

机构地区：[1]河北省石家庄市第二医院检验科,050051

出　　处：《河北医药》2022年第20期3131-3134,共4页Hebei Medical Journal

基　　金：石家庄市科学技术研究与发展计划项目(编号:211460633)。

摘　　要：目的探讨T2DM患者血清APN水平、糖化白蛋白(GA)和糖化血红蛋白(HbA1c)比值(GA/HbA1c)与糖尿病周围神经病变(DPN)的相关性。方法随机选取2021年7~12月住院的T2DM患者120例,根据患者临床资料及神经传导功能检查(NCS)分为T2DM不伴周围神经病变组(NDPN)和T2DM并发周围神经病变组(DPN)。比较2组一般资料及生化指标、脂联素(APN)水平、血糖控制指标,采用多因素logistic回归分析T2DM患者并发DPN的独立危险因素,受试者工作特征(ROC)曲线分析差异指标的预测价值。结果120例T2DM患者中检出NDPN组47例、DPN组73例。DPN组患者血清DM病程、DBP、BUN的水平均高于NDPN组,差异有统计学意义(P<0.05)。与NDPN组相比,DPN组APN、FPG、GA水平及GA/HbA1c比值均较高(P<0.05)。Logistic回归分析显示,APN、DM病程及GA/HbA1c是导致T2DM患者并发DPN的独立危险因素。ROC曲线分析显示,APN、DM病程、GA/HbA1c比值对DPN患病预测的曲线下面积(AUC)分别为0.893、0.715、0.808。结论血清APN水平降低和GA/HbA1c比值升高可能是预测T2DM并发DPN的良好指标。Objective To investigate the correlation between serum adiponectin,glycosylated albumin(GA)and glycosylated hemoglobin(HbA1c)ratio(GA/HbA1c)and diabetic peripheral neuropathy(DPN)in patients with type 2 diabetes mellitus(T2DM).Methods A total of 120 patients with T2DM who were treated in our hospital from July 2021 to December 2021 were enrolled in the study.According to NCS examination results,these patients were divided into NDPN group(without peripheral neuropathy group)and DPN group(with DPN).The general data,biochemical indicators,adiponectin level and blood glucose control indicators were observed and compared between the two groups.Moreover the independent risk factors of DPN were analyzed by multivariate Logistic regression,and the predictive value of the difference indicators was analyzed by receiver operating characteristic(ROC)curve.Results Of the 121 patients,there were 47 cases of NDPN and 73 cases of DPN.The levels of DBP and BUN in DPN group were significantly higher than those in NDPN group(P<0.05).And the levels of FPG,GA and GA/HbA1c ratio in DPN group were significantly higher than those in NDPN group(P<0.05).Logistic regression analysis showed that adiponectin,DM duration and GA/HbA1c were the independent risk factors for DPN in patients with T2DM.Moreover ROC curve analysis showed that the area under curve(AUC)of adipectin,DM,GA/HbA1c ratio for DPN was 0.893,0.715,0.808,respectively.Conclusion The decrease of serum levels of adiponectin and the increase of GA/HbA1c ratio may be the good indxes for predicting the occurrence of DPN in patients with T2DM.

关 键 词：2型糖尿病 糖尿病周围神经病变 GA/HbA1c 脂联素 

分 类 号：R587.25[医药卫生—内分泌]