3D-ASL磁共振成像对正常中老年人各脑区血流量的测量  

3D Arterial Spin-labeling MR:Cerebral Blood Flow Measurement in Middle Aged and Elderly People

作　　者：刘梦秋 刘婕 曾飞雁 刘影[1] LIU Meng-qiu;LIU Jie;ZENG Fei-yan;LIU Ying(Department of Radiology,the First Affiliated Hospital of University of Science and Technology of China(Anhui Provincial Hospital),Hefei 230001,China)

机构地区：[1]中国科学技术大学附属第一医院(安徽省立医院),安徽合肥230001

出　　处：《中国CT和MRI杂志》2022年第12期1-3,共3页Chinese Journal of CT and MRI

摘　　要：目的探讨3D-ASL测量正常中老年人各脑区的血流量及性别、年龄对其的影响。方法抽取在我院行头颅MRI T1WI、T2WI及Flair序列检查正常及TOF MRA检查无脑血管异常的体检者共102例,其中男性37例,女性65例为研究对象。按年龄分为2组,中年组(50~59岁)36例和老年组(≥60岁)66例,行3D-ASL检查,PLD时间选取2025ms。选取对称脑区的ROI,测量各脑区CBF值。对双侧对称脑区CBF值计算该脑区CBF均值。采用配对t检验,分析双侧对称脑区的CBF值差异,采用方差分析,分析各年龄组及性别组间差异(P<0.05有统计学意义),采用Pearson相关分析分析各组间、各脑区间CBF值有无相关性。结果双侧对称脑区的CBF值差异无统计学意义(P>0.05);中年组各脑区CBF值均高于老年组,但组间方差分析CBF值的差异无统计学意义(P值>0.05);女性各脑区CBF值高于男性,其中双侧顶叶、左侧枕叶、小脑及丘脑间的差异均具有统计学意义。Pearson相关分析显示各脑区CBF值与年龄无明显相关性,双侧顶叶、左额叶、左枕叶、双侧小脑及丘脑的CBF值与性别存在相关性。结论采用3D-ASL技术测量各脑区CBF值时,年龄对各脑区的CBF值无明显影响。女性各脑区CBF值均低于男性,男女性左额叶、左枕叶、双侧小脑及丘脑的CBF值差异均具有统计学意义。Objective To explore the effect of 3D ASL measurement on cerebral blood flow of normal middle-aged and old people.Methods 102 healthy persons(37 males and 65 females)were selected from our hospital who had normal routine physical examination items,neurological examination and MRI examination.They were divided into two groups according to their ages:36 cases in middle age group(50~59 years old)and 66 cases in old age group(≥60 years old),3D ASL inspection was performed and PLD time was 2025ms.ROI selected the bilateral symmetrical regions,calculated the mean CBF values of bilateral symmetrical brain regions.Paired t-test was used to analyze the differences in CBF values between bilateral symmetrical brain regions,ANOVA was used to analyze the differences between groups in each age group and sex(P<0.05 was statistically significant),and Pearson's correlation was used to analyze the differences in CBF values among groups and between each brain interval with or without correlation.Results there were no significant differences in CBF values between bilateral symmetrical brain regions(P>0.05);The mean CBF of all brain regions in the middle-aged group was higher than that of each brain region in the older age group,but there was no significant difference in CBF values between groups by ANOVA(P values>0.05);The mean CBF of each brain region was higher in women than in men,with statistically significant differences between bilateral parietal,left occipital,cerebellar,and thalamic regions.Pearson correlation analysis showed no significant correlation between cortical CBF values and age in each brain region,and there was a correlation between cortical CBF values and gender in bilateral parietal,left frontal,left occipital,bilateral cerebellar,and thalamocortical regions.Conclusion When the CBF values of each brain region were measured by 3d-asl technique,the age factor had no obvious influence on the CBF values of each brain region.CBF values in all brain regions were lower in women than in men,with statistically signific

关 键 词：年龄 性别 磁共振成像 动脉自旋标记 脑血流量 

分 类 号：R81[医药卫生—放射医学]