MRI对血液肿瘤病患者肝脏铁过载的评估价值分析  

Analysis of Evaluated Value of MRI on Liver Iron Overload in Patients with Hematological Tumors

作　　者：王晓芳[1] 严敏[2] 曹季军 WANG Xiao-fang;YAN Min;CAO Ji-jun(Imaging Department,Taicang Hospital Affiliated to Suzhou University,Suzhou 215400,Jiangsu Province,China;Hematology Oncology Department,Taicang Hospital Affiliated to Suzhou University,Suzhou 215400,Jiangsu Province,China;Laboratory Department,Taicang Hospital Affiliated to Suzhou University,Suzhou 215400,Jiangsu Province,China)

机构地区：[1]苏州大学附属太仓医院影像科,江苏苏州215400 [2]苏州大学附属太仓医院血液肿瘤科,江苏苏州215400 [3]苏州大学附属太仓医院检验科,江苏苏州215400

出　　处：《中国CT和MRI杂志》2022年第12期115-117,共3页Chinese Journal of CT and MRI

摘　　要：目的探究MRI对血液肿瘤病患者肝脏铁过载(IO)的评估价值。方法本研究针对我院2019年7月至2020年3月收治的20例血液病患者及30例肿瘤患者采取回顾性研究分析,选取同期来我院健康体检人员18例为健康组。比较三组血清铁蛋白(SF)、肝脏弛豫率R2*值、肝铁浓度(LIC)指标;分析R2*、LIC指标对血液肿瘤患者IO的诊断价值;分析血清SF与R2*、LIC指标的相关性。结果血液病组血清SF、R2*、LIC指标[(856.27±522.79)ng/mL、(253.91±220.45)Hz、(6.65±5.61)mg/g DW]明显高于肿瘤组[(523.76±437.42)ng/mL、(87.16±74.51)Hz、(2.42±1.89)mg/g DW]及健康组[(93.06±96.15)ng/mL、(40.01±7.99)Hz、(1.22±0.21)mg/g DW](P<0.05);IO组R2*、LIC指标[(350.56±243.77)Hz、(9.11±6.19)mg/g DW]明显高于非IO组[(91.18±65.72)Hz、(2.43±1.76)mg/g DW]。R2*临界值为114.11 Hz时评估肝脏IO的敏感度、特异性分别为92.31%、72.97%,曲线下面积(AUC)为0.835;LIC临界值为4.32 mg/g DW时评估肝脏IO的敏感度、特异性分别为76.92%、83.78%,AUC为0.833;血液病组R2*、LIC指标与SF(r=0.706、0.693,P<0.05)呈正相关,肿瘤组R2*、LIC指标与SF呈正相关(r=0.499、0.391,P<0.05)。结论MRI检测R2*、LIC水平对评估血液肿瘤患者铁过载有较高的价值。Objective To explore the evaluated value of MRI on liver iron overload(IO)in patients with hematological tumors.Methods A retrospective analysis was performed on 20 patients with hematological diseases and 30 patients with tumors treated in the hospital between July 2019 and March 2020,and 18 patients who came to the hospital for physical examination during the same period were selected as healthy group.Serum ferritin(SF),liver relaxation rate R2*value and liver iron concentration(LIC)were compared among the three groups.The diagnostic value of R2*and LIC on IO in patients with hematological tumors was analyzed,and the correlation between serum SF and R2*and LIC was also analyzed.Results Serum SF,R2*and LIC of[(856.27±522.79)ng/mL,(253.91±220.45)Hz,(6.65±5.61)mg/g DW]in hematological disease group were significantly higher than[(523.76±437.42)ng/mL,(87.16±74.51)Hz,(2.42±1.89)mg/g DW]in tumor group and[(93.06±96.15)ng/mL,(40.01±7.99)Hz,(1.22±0.21)mg/g DW]in healthy group(P<0.05).R2*and LIC of[(350.56±243.77)Hz,(9.11±6.19)mg/g DW]in IO group were significantly higher than[(91.18±65.72)Hz,(2.43±1.76)mg/g DW]in non-IO group.When the critical value of R2*was 114.11 Hz,the sensitivity and specificity of evaluating liver IO were 92.31%and 72.97%and the area under the curve(AUC)was 0.835.When the critical value of LIC was 4.32 mg/g DW,the sensitivity,specificity and AUC of liver IO evaluation were 76.92%,83.78%and 0.833 respectively.The R2*and LIC of hematological disease group were positively correlated with SF(r=0.706,0.693,P<0.05),and the R2*and LIC in tumor group were positively correlated with SF(r=0.499,0.391,P<0.05).Conclusion MRI detection of R2*and LIC is of high value in assessing iron overload in patients with hematological tumors.

关 键 词：磁共振成像 血液病 肿瘤 肝脏铁过载 

分 类 号：R445.2[医药卫生—影像医学与核医学]