MSCT灌注成像参数与胃癌患者病理分级及肿瘤因子的关系  

The Relationship between MSCT Perfusion Imaging Parameters and Pathological Grading,Tumor Factors in Patients with Gastric Cancer

作　　者：吕广营 刘义 张雪瑞 LV Guang-ying;LIU Yi;ZHANG Xue-rui(Intervention Operating Room of the Second People's Hospital,Zhengzhou 451191,Henan Province,China)

机构地区：[1]河南省第二人民医院介入手术室,河南郑州451191

出　　处：《中国CT和MRI杂志》2022年第12期139-141,共3页Chinese Journal of CT and MRI

摘　　要：目的探讨多层CT(MSCT)灌注成像参数与胃癌患者病理分级及肿瘤因子的关系。方法选取2019年3月至2021年3月两年内在本院确诊的64例胃癌患者作为胃癌组,根据患者的肿瘤细胞组织的病理分化程度分为中高分化组和低分化组。并选取同期的健康体检人群64例作为对照组,收集胃癌患者的MSCT灌注成像参数,即达峰时间(TTP)、血流量(BF)、Patlak表面通透性(PPS)及血容量(PBV)和所有入试者的肿瘤因子,即甲胎蛋白(AFP)、糖抗原72-4(CA72-4)、糖类抗原19-9(CA19-9)、血清癌胚抗原(CEA)、肿瘤坏死因子-α(TNF-α),比较胃癌患者组间的MSCT灌注各参数的差异,各组间的AFP、CA72-4、CA19-9、CEA、TNF-α的差异,并分析胃癌患者MSCT灌注成像参数的与患者的病理分级及肿瘤因子的相关性。结果中高分化组胃癌患者的TTP、PPS、PBV值均小于低分化组(P<0.05);胃癌组患者的AFP、CA72-4、CA19-9、CEA水平明显高于对照组(P<0.05);胃癌患者的TTP、BF、PBV值与AFP、CA72-4、CA19-9、CEA水平无明显的相关性(P>0.05),胃癌患者的PPS值与AFP、CA72-4、CA19-9、CEA水平呈正相关(r=0.254、0.295、0.241、0.260,P<0.05)。结论胃癌患者的MSCT灌注成像参数的变化可以反映患者的病理组织的分化程度,且患者的MSCT灌注成像参数PPS与肿瘤因子水平具有相关性。Objective To explore the relationship between perfusion imaging parameters of multi-slice CT(MSCT)and pathological grading,tumor factors in patients with gastric cancer.Methods A total of 64 patients with gastric cancer confirmed in the hospital were enrolled as gastric cancer group between March 2019 and March 2021.According to histopathologic differentiation degree of tumor cells,they were divided into moderate-high differentiation group and low differentiation group.And other 64 healthy controls during the same period were enrolled as control group.MSCT perfusion imaging parameters[time to peak(TTP),blood flow(BF),Patlak permeability surface(PPS),blood volume(PBV)]in gastric cancer patients and tumor factors[alpha-fetoprotein(AFP),carbohydrate antigen 72-4(CA72-4),carbohydrate antigen 19-9(CA19-9),serum carcinoembryonic antigen(CEA),tumor necrosis factor-α(TNF-α)]in all objects were collected.The differences in MSCT perfusion parameters,AFP,CA72-4,CA19-9,CEA and TNF-αbetween moderate-high differentiation group and low differentiation group were compared.The correlation between MSCT perfusion imaging parameters and pathological grading,tumor factors in patients with gastric cancer was analyzed.Results TTP,PPS and PBV values in moderate-high differentiation group were lower than those in low differentiation group(P<0.05).The levels of AFP,CA72-4,CA19-9 and CEA in gastric cancer group were significantly higher than those in control group(P<0.05).TTP,BF and PBV values were not significantly correlated with AFP,CA72-4,CA19-9 and CEA(P>0.05),while PPS value was positively correlated with AFP,CA72-4,CA19-9 and CEA(r=0.254,0.295,0.241,0.260,P<0.05).Conclusion The changes of MSCT perfusion imaging parameters can reflect differentiation degree of pathological tissues in patients with gastric cancer.There is correlation between PPS and tumor factors.

关 键 词：多层CT灌注成像 胃癌 病理分级 肿瘤因子 

分 类 号：R445.3[医药卫生—影像医学与核医学]