动脉粥样硬化易损斑块无创检测的分子影像研究进展  

The Progress of Molecular Imaging in Non-Invasive Detection of Atherosclerotic Vulnerable Plaque

作　　者：丁恩慈[1] 陆东燕[1] 魏利娟 沈婕[1] DING En-ci;LU Dong-yan;WEI Li-juan;SHEN Jie(Department of Nuclear Medicine,Tianjin First Central Hospital,24 Fu Kang Road,Tianjin 300192,China)

机构地区：[1]天津市第一中心医院核医学科,天津300192

出　　处：《中国CT和MRI杂志》2022年第12期184-185,187,共3页Chinese Journal of CT and MRI

基　　金：天津市卫生健康科技项目,面上项目(TJWJ2021MS013);天津市第一中心医院科技基金(2020CF25);天津市医学重点学科(专科)建设项目资助(TJYXZDXK-041A);天津市应用基础研究多元投入基金项目(21JCYBJC01060)。

摘　　要：随着动脉粥样硬化发病率增高,中风呈年轻化趋势。提前识别易损斑块、防止其成为罪犯血管是心血管病预防的重要方向。分子影像探针用于早期无创性检测动脉粥样硬化易损斑块是近年来的研究热点。它们能从代谢、分子层面实时地探寻在体状态下的病生理过程,检测炎症和微钙化等微观过程,无创地观察动脉粥样硬化程度、斑块的代谢情况,监测斑块进展及治疗效果,并探寻它们与心血管疾病风险的关联性,对及时改善心血管疾病的诊断和管理体系有着重要的临床价值。With increasing of the incidence of atherosclerosis,stroke is showing a younger trend.Identifying vulnerable plaques in advance and preventing them from becoming blood vessels of criminals are important direction in the prevention of cardiovascular diseases.Molecular imaging probes and related nanoprobes for early noninvasive detection of atherosclerotic vulnerable plaque are the focus of research in recent years.They can explore the pathophysiological process in the body in real time from the metabolic and molecular levels,and detect inflammation and microcalcification and other micro-processes,and noninvasively observe the degree of atherosclerosis and the metabolism of plaque monitering the progress of plaque and the treatment effects,and explore their relationship with cardiovascular disease risk,so as to improve the diagnosis and the management system of cardiovascular disease in a timely manner with important clinical value.

关 键 词：动脉粥样硬化 易损斑块 分子影像 PET/CT 

分 类 号：R543.5[医药卫生—心血管疾病] R816.2[医药卫生—内科学]