产气荚膜梭菌α毒素作用机制研究进展  

Research progress in mechanisms of Clostridium perfringens α toxin

作　　者：郭子槊 辛文文 王景林 GUO Zi-shuo;XIN Wen-wen;WANG Jing-lin(State Key Laboratory of Pathogen and Biosecurity,Institute of Microbiology and Epidemiology,Academy of Military Med-ical Sciences,Academy of Military Sciences,Beijing 100071,China)

机构地区：[1]军事科学院军事医学研究院微生物流行病研究所病原微生物生物安全国家重点实验室,北京100071

出　　处：《军事医学》2022年第9期711-714,共4页Military Medical Sciences

摘　　要：毒素是产气荚膜梭菌的主要毒力因子之一,具有磷脂酶C和鞘磷脂酶两种酶活性,能水解宿主细胞膜上的磷脂酰胆碱和鞘磷脂,导致多种人畜疾病。同时,该毒素也是一种潜在的生物战剂,对国家生物安全存在潜在威胁。该文主要对产气荚膜梭菌α毒素的生物学结构与性质、细胞毒性作用的信号通路、激活血小板的分子机制以及治疗方面进行综述。Alpha toxin,one of the main virulence factors of Clostridium perfringens,is capable of two enzymatic activities,phospholipase C and sphingomyelinase. Alpha toxin can hydrolyze phosphatidylcholine and sphingomyelin on cell membranes,resulting in a variety of human and animal diseases. At the same time,α toxin is also a potential biological warfare agent,which is of great significance for national biosecurity. This paper provides an overview of the biological structure and properties of C.perfringens α toxin,signaling pathways of toxin cell toxicity,molecular mechanisms of platelet activation,and therapeutic value.

关 键 词：产气荚膜梭菌 Α毒素 细胞毒性作用 溶血机制 血小板 

分 类 号：S852.61[农业科学—基础兽医学]