基于人类胎盘体外循环灌注模型探讨艾司西酞普兰的胎盘透过性  

Placental Permeability of Escitalopram Based on Human Placental Extracorporeal Circulation Perfusion Model

作　　者：姚勤[1] 王晶晶[1] 李骞[1] 王思捷[1] 黄桦[1] 柳汝明[1] 张峻[1] YAO Qin;WANG Jingjing;LI Qian;WANG Sijie;HUANG Hua;LIU Ruming;ZHANG Jun(Dept.of Clinical Pharmacy,the First Affiliated Hospital of Kunming Medical University,Kunming 650032,China)

机构地区：[1]昆明医科大学第一附属医院临床药学科,昆明650032

出　　处：《中国医院用药评价与分析》2022年第11期1306-1309,1314,共5页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：云南省卫生和计划生育委员会医学人才培养计划项目(No.L-201614,No.D-2018043,No.H-2017051,No.H-2018081);云南省教育厅科学研究基金项目(No.2019J1237);云南省基础研究计划—昆医联合专项项目(No.2019FE001-208)。

摘　　要：目的:应用人胎盘体外循环灌注模型,对艾司西酞普兰进行胎盘透过性研究。方法:选择刚娩出的健康足月人胎盘,建立胎盘体外循环灌注模型,循环灌注3 h,期间从母体池和子体池取样,检测pH、氧分压、β-人绒毛膜促性腺激素、葡萄糖消耗量、乳酸生成量、子体池液体损耗量以及阳性对照物安替比林和艾司西酞普兰的浓度以评估其胎盘透过率。结果:本研究共进行了158例人类胎盘体外循环灌注模型的建立,符合模型建立成功标准的有15例。3 h循环灌注后,艾司西酞普兰胎盘透过率为(9.09±2.80)%,相对透过率为(23.35±4.37)%。结论:艾司西酞普兰可少量透过胎盘而导致胎儿暴露于艾司西酞普兰中。OBJECTIVE:To probe into the placental permeability of escitalopram by human placental extracorporeal circulation perfusion model.METHODS:Healthy and full-term human placentas that had just been delivered were selected,the placental extracorporeal circulation perfusion model was established and circularly perfused for 3 h.During this period,samples were taken from the maternal pool and the fetal pool,and the pH,PO_(2),β-human chorionic gonadotropin,glucose consumption,lactate production,fluid loss from the fetal pool,the concentrations of positive controls of antipyrine and escitalopram were detected to assess the placental transmission rates.RESULTS:In this study,158 human placental extracorporeal circulation perfusion models were performed,and 15 cases met the criteria for successful model establishment.After 3 h of circulation perfusion,the placental permeation rate of escitalopram was(9.09±2.80)%and the relative permeation rate was(23.35±4.37)%.CONCLUSIONS: Escitalopram can penetrate the placenta in small dose and lead to fetal exposure to escitalopram.

关 键 词：艾司西酞普兰 胎盘转运 体外人胎盘灌注模型 

分 类 号：R971.4[医药卫生—药品]