奥硝唑氯化钠注射液治疗支气管哮喘合并感染的疗效及对病原菌清除率的影响  

Efficacy of Ornidazole Sodium Chloride Injection in the Treatment of Bronchial Asthma Complicated with Infection and Its Effects on Clearance Rate of Pathogenic Bacteria

作　　者：曹美艳 黄量 卢平[2] CAO Meiyan;HUANG Liang;LU Ping(Dept.of Pharmacy,Affiliated Hospital of Xiangnan University,Hunan Chenzhou 423000,China;Dept.of Respiratory Medicine,Affiliated Hospital of Xiangnan University,Hunan Chenzhou 423000,China)

机构地区：[1]湘南学院附属医院药剂科,湖南郴州423000 [2]湘南学院附属医院呼吸科,湖南郴州423000

出　　处：《中国医院用药评价与分析》2022年第11期1322-1325,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：湖南省自然科学基金项目(No.2020JJ2025)。

摘　　要：目的:探讨奥硝唑氯化钠注射液治疗支气管哮喘(BA)合并感染的疗效及对病原菌清除率的影响。方法:按随机数字表法将2019年6月至2021年6月该院收治的BA合并感染患者86例分为研究组(43例)、对照组(43例)。对照组患者采用头孢哌酮钠他唑巴坦钠治疗,研究组患者在对照组的基础上加用奥硝唑氯化钠注射液治疗。比较两组患者的疗效、症状改善情况、细菌清除率及不良反应发生情况,治疗前后肺功能[用力肺活量(FVC)、第1秒用力呼气容积(FEV)、最大呼气流速占预计值百分比(PEF%)和最大呼气中段流量(MMF)]、炎症因子[白细胞介素4(IL-4)、白细胞介素6(IL-6)和肿瘤坏死因子α(TNF-α)]水平。结果:研究组患者的总有效率、细菌清除率分别为95.35%(41/43)、93.02%(40/43),明显高于对照组的79.07%(34/43)、72.09%(31/43),差异均有统计学意义(P<0.05)。研究组患者症状改善时间较对照组更短,差异有统计学意义(P<0.05)。治疗后,研究组患者血清IL-4、IL-6和TNF-α水平较对照组低,差异均有统计学意义(P<0.05)。研究组、对照组患者不良反应发生率分别为16.28%(7/43)、6.98%(3/43),差异无统计学意义(P>0.05)。结论:奥硝唑氯化钠注射液治疗BA合并感染患者效果显著,可有效促使患者症状改善,提高细菌清除率,减轻机体炎症,改善肺功能,且安全性高。OBJECTIVE:To probe into the efficacy of ornidazole sodium chloride injection in the treatment of bronchial asthma(BA)complicated with infection and its effects on clearance rate of pathogenic bacteria.METHODS:A total of 86 patients with BA complicated with infection admitted into this hospital from Jun.2019 to Jun.2021 were selected and divided into research group(43 cases)and control group(43 cases)via the random number table.The control group was treated with cefoperazone sodium tazobactam sodium,while the research group was given ornidazole sodium chloride injection based on the control group.The efficacy,symptom improvement,bacterial clearance rate and incidences of adverse drug reactions,pulmonary function[forced vital capacity(FVC),forced expiratory volume in 1 s(FEV),proportion of peak expiratory flow accounted for its predicted value(PEF%)and maximum mid-expiratory flow(MMF)]and inflammatory factors levels[interleukin 4(IL-4),interleukin 6(IL-6)and tumor necrosis factorα(TNF-α)]before and after treatment were compared between two groups.RESULTS:The total effective rate and bacterial clearance rate of research group were respectively 95.35%(41/43)and 93.02%(40/43),significantly higher than those of the control group(79.07%,34/43;72.09%,31/43),with statistically significant differences(P<0.05).The symptom improvement time of research group was shorter than that of the control group,with statistically significant difference(P<0.05).After treatment,the serum IL-4,IL-6 and TNF-αlevels of research group were significantly lower than those of the control group,with statistically significant differences(P<0.05).The incidences of adverse drug reactions of research group and control group were respectively 16.28%(7/43)and 6.98%(3/43),the difference was not statistically significant(P>0.05).CONCLUSIONS:The efficacy of ornidazole sodium chloride injection in the treatment of BA complicated with infection is remarkable,which can promote symptom improvement,increase bacterial clearance rate,relieve body inflammation

关 键 词：支气管哮喘 奥硝唑氯化钠注射液 病原菌清除率 感染 免疫功能 

分 类 号：R974[医药卫生—药品]