头孢哌酮舒巴坦治疗妇产科感染有效性和安全性的系统评价  

Systematic Review of Efficacy and Safety of Cefoperazone Sulbactam in Obstetrics and Gynecology Infections

作　　者：李代晓 应颖秋[1,3] 杨丽[1] 翟所迪 LI Daixiao;YING Yingqiu;YANG Li;ZHAI Suodi(Dept.of Pharmacy,Peking University Third Hospital,Beijing 100191,China;Dept.of Pharmacy,Affiliated Hospital of Chengde Medical College,Hebei Chengde 067000,China;Institute for Drug Evaluation,Peking University Health Science Center,Beijing 100191,China)

机构地区：[1]北京大学第三医院药剂科,北京100191 [2]承德医学院附属医院药学部,河北承德067000 [3]北京大学医学部药物评价中心,北京100191

出　　处：《中国医院用药评价与分析》2022年第11期1361-1364,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：国家科技重大专项子课题(No.2017ZX09101001-007-001)。

摘　　要：目的:系统评价头孢哌酮舒巴坦治疗妇产科感染的有效性和安全性。方法:检索the Cochrane Library、PubMed、Embase、中国知网及万方数据库,截至2021年6月,收集头孢哌酮舒巴坦治疗妇产科感染的随机对照试验(RCT,观察组患者使用头孢哌酮舒巴坦治疗,对照组患者使用头孢他啶治疗)。由2名研究者按照纳入和排除标准筛选文献、提取资料并进行方法学质量评价,采用RevMan 5.3软件对数据进行Meta分析,效应值为比值比(OR)及其95%CI。结果:最终纳入8篇RCT文献,共1527例患者。Meta分析结果显示,观察组患者的治疗总有效率高于对照组(OR=4.09,95%CI=2.77~6.06,P<0.00001),细菌清除率高于对照组(OR=2.48,95%CI=1.75~3.51,P<0.00001),组间差异均有统计学意义;观察组与对照组患者不良反应发生率比较,差异无统计学意义(OR=0.69,95%CI=0.45~1.04,P=0.08)。结论:研究结果显示,头孢哌酮舒巴坦应用于妇产科感染的临床疗效优于头孢他啶,并具有良好的安全性。OBJECTIVE:To systematically evaluate the efficacy and safety of cefoperazone sulbactam in the treatment of obstetrics and gynecological infections.METHODS:The Cochrane Library,PubMed,Embase,CNKI and Wanfang Data till Jun.2021 were retrieved to collect randomized controlled trial(RCT)of cefoperazone sulbactam in the treatment of obstetrics and gynecological infections(the observation group was treated with cefoperazone sulbactam,while the control group received ceftazidime).According to inclusion and exclusion criteria,data were extracted,and methodological quality was evaluated by two researchers.Meta-analysis was performed by using RevMan 5.3 software,and the effect values were odds ratio(OR)and 95%CI.RESULTS:Eight RCT with a total of 1527 patients were finally included in the literature.Meta-analysis showed that the total effective rate of the observation group was higher than that of the control group(OR=4.09,95%CI=2.77-6.06,P<0.00001),and the bacterial clearance rate was higher than that of the control group(OR=2.48,95%CI=1.75-3.51,P<0.00001),the differences were statistically significant.There was no significant difference in the incidence of adverse drug reactions between the observation group and control group(OR=0.69,95%CI=0.45-1.04,P=0.08).CONCLUSIONS:The efficacy of cefoperazone sulbactam in the treatment of obstetrics and gynecological infections is significant with higher safety.

关 键 词：头孢哌酮舒巴坦 妇产科感染 有效性 安全性 

分 类 号：R978.1[医药卫生—药品]