15家城市医疗机构孕妇分娩年龄与妊娠并发症和妊娠结局的相关性研究  

Association of maternal age at delivery with pregnancy complications and pregnancy outcomes in 15 urban hospitals

作　　者：王雪茵[1] 隽娟 周敏[1] 王旭[1] 张小松[1] WANG Xueyin;JUAN Juan;ZHOU Min;WANG Xu;ZHANG Xiaosong(Department of Obstetrics and Gynecology,Peking University First Hospital,Beijing 100034,China)

机构地区：[1]北京大学第一医院妇产科,北京100034

出　　处：《中国妇幼健康研究》2022年第11期24-30,共7页Chinese Journal of Woman and Child Health Research

基　　金：国家自然科学基金资助项目(82103907)。

摘　　要：目的 探讨分娩年龄与妊娠并发症/合并症、妊娠结局的关系。方法 选择在北京市、广东省、湖南省、湖北省、四川省和陕西省的15家省市级医疗保健机构分娩的孕22周及以上的活产产妇,于2012年4月1日至2013年的3月31日每个季度第3个月的10—19日,即2012年的6、9、12月及2013年的3月共4个月的10—19日采用自制问卷对产妇进行调查,调查时间共计40天,回收合格问卷9 152份,问卷内容包括产妇的人口学特征、妊娠史、孕产期并发症/合并症、妊娠结局等。根据分娩年龄将产妇分为5组:<20岁组、20~24岁组、25~29岁组、30~34岁组、35~39岁组、≥40岁组。比较各组间妊娠并发症/合并症和妊娠结局发生情况的差异。结果 分娩年龄<20岁者共68例(0.7%),高龄妊娠者(35~<40岁组及≥40岁组)794例(7.7%)。与25~29岁组比较:(1)轻度贫血在20~24岁组、中度贫血在<20岁组、妊娠合并高血压在≥40岁组的发生风险增加,OR(95%CI)值分别为1.296(1.038~1.618)、4.519(1.369~14.915)、4.552(1.018~20.350),P<0.05;(2)妊娠期糖尿病在30~34岁组、35~39岁组及≥40岁组的发生风险增加,OR(95%CI)值分别为1.633(1.392~1.916)、2.086(1.644~2.646)、1.795(1.118~2.880),P<0.05;(3)前置胎盘在35~39岁组及≥40岁组的发生风险增加,OR(95%CI)值分别为1.986(1.228~3.212)、3.529(1.735~7.176),P<0.05;(4)剖宫产在30~34岁组、35~39岁组及≥40岁组的发生风险增加,OR(95%CI)值分别为1.374(1.244~1.517)、2.386(2.001~2.845)、2.503(1.762~3.556),P<0.05;(5)早产在<20岁组、20~24岁组、30~34岁组、35~39岁组及≥40岁组的发生风险增加,OR(95%CI)值分别为3.824(2.209~6.620)、1.574(1.303~1.901)、1.309(1.111~1.543)、1.841(1.446~2.345)、1.894(1.200~2.987),P<0.05;(6)低出生体重在<20岁组、20~24岁组、35~39岁组及≥40岁组的发生风险增加,OR(95%CI)值分别为3.782(2.000~7.152)、1.435(1.130~1.822)、1.561(1.142~2.133)、2.389(1.436~3.975),P<0.05;(7)新生儿转NICU在<20岁组�Objective To explore the association of maternal age at delivery with pregnancy complications/comorbidities and pregnant outcomes.Methods Women who delivered live birth at≥22 weeks of gestation in 15 provincial and municipal health care institutions in Beijing, Guangdong, Hunan, Hubei, Sichuan and Shaanxi were selected.During the 10-19 th days of the third month of each quarter between April 1,2012 and March 31,2013,that is, during the 10-19 th days of the 4 months including June, September, December, 2012 and March, 2013,a self-made questionnaire was used to investigate the puerperae for a total of 40 days.A total of 9 152 qualified questionnaires were recovered.The contents of the questionnaire included demographic characteristics, pregnancy history, pregnancy complications/complications, and pregnancy outcomes.Participants were divided into 5 groups according to the age of delivery: the<20 years group, the 20-24 years group, the 25-29 years group, the 30-34 years group, the 35-39 years group and the≥40 years group.The differences of the incidences of pregnancy complications/complications and pregnancy outcomes were compared among the groups.Results The age of delivery in 68 cases(0.7%) were<20 years old, and 794 cases(7.7%) were of advanced pregnancy(35-<40 years group and≥40 years group).Compared with the 25-29 years group,(1)the risks of mild anemia in the 20-24 years group, moderate anemia in the<20 years group, pregnancy-induced hypertension in the≥40 years group increased, and the OR and 95%CI were 1.296(1.038-1.618),4.519(1.369-14.915) and 4.552(1.018-20.350),respectively, P<0.05.(2)The risk of gestational diabetes mellitus in the 30-34 years group, the 35-39 years group and the≥40 years group increased, and the OR and 95%CI were 1.633(1.392-1.916),2.086(1.644-2.646) and 1.795(1.118-2.880),respectively, P<0.05.(3)The risk of placenta previa in the 35-39 years group and the≥40 years group increased, and the OR and 95%CI were 1.986(1.228-3.212) and 3.529(1.735-7.176),respectively, P<0.05.(4)The

关 键 词：分娩年龄 妊娠并发症/合并症 妊娠结局 高危妊娠 

分 类 号：R173[医药卫生—妇幼卫生保健]