脂代谢紊乱与椎间盘退变的关系研究进展  

Research progress on relationship between lipid metabolism disorder and intervertebral disc degeneration

作　　者：谭兵 朱宁[2] 胡侦明 TAN Bing;ZHU Ning;HU Zhen-ming(Department of Spine Surgery,The Third Hospital of Mianyang City,Sichuan Mental Health Center,Mian-yang 621000,China;Southwest University of Science and Technology,Mianyang 621000,China;Department of Orthopedics,The First Affiliated Hospital,Chongqing Medical University,Chongqing,400000,China)

机构地区：[1]绵阳市第三人民医院(四川省精神卫生中心)脊柱外科,四川绵阳621000 [2]西南科技大学,四川绵阳621000 [3]重庆医科大学附属第一医院骨科,重庆400000

出　　处：《中国矫形外科杂志》2022年第19期1766-1770,共5页Orthopedic Journal of China

摘　　要：椎间盘退行性变(inter-vertebral disc degeneration,IVDD)是一种慢性、发病率高、治疗费用昂贵、易复发的退变性疾病。目前对于IVDD的病因和发病机制仍不清楚,至今尚无有效的治疗方法。近期研究表明,除了异常、过度的机械负荷和炎症外,脂代谢紊乱可能是IVDD的重要病因。研究表明除了体重本身对椎间盘退变的力学影响,脂代谢紊乱来源的蛋白质、脂肪因子和多种脂质介质,如脂肪酸,氧化低密度脂蛋白、瘦素等与IVDD密切相关。本综述的目的是总结有关脂代谢紊乱及相关产物与IVDD发病机制之间相互关系的最新发现,特别强调脂质和脂肪因子的作用并探究脂代谢紊乱致椎间盘退变的具体机制。Intervertebral disc degeneration(IVDD)is a chronic degenerative disease and prone to recurrence with high incidence and expensive treatment burden.Up to now the etiology and pathogenesis of IVDD remain unclear without effective treatment in some extent.Recent evidences show that in addition to abnormal and excessive mechanical load and inflammation,lipid metabolism disorder may be an important cause of IVDD.Beside the mechanical effect of body weight on intervertebral disc degeneration,adipokines,the lipid mediators derived from lipid metabolism disorders,including fatty acids,oxidized low-density lipoproteins and leptin,are closely related to IVDD.The purpose of this review is to summarize the latest findings on the relationship between lipid metabolism disorders and related products and their role in pathogenesis of IVDD,with particular emphasis on the role of lipids and adipokines and to explore the specific mechanism of intervertebral disc degeneration caused by lipid metabolism disorders.

关 键 词：脂质 脂肪因子 椎间盘退变 高脂血症 

分 类 号：R681.5[医药卫生—骨科学]