Bax抑制因子Ⅰ对冠状动脉造影术后患者发生造影剂肾病的预测价值  

Predictive value of Bax inhibitor-1 in contrast induced nephropathy after coronary arteriography

作　　者：韦娟余 郑东辉 Wei Juan-yu;Zheng Dong-hui(Affiliated Huai’an Hospital,Xuzhou Medical University,Huai'an 223002,China)

机构地区：[1]徐州医科大学附属淮安医院,淮安223002

出　　处：《临床肾脏病杂志》2022年第11期889-893,共5页Journal Of Clinical Nephrology

摘　　要：目的探讨血清、尿液Bax抑制因子Ⅰ(Bax inhibitar-1,BI-1)1水平对冠状动脉造影术(coronary arteriography,CAG)术后发生造影剂肾病(contrast-induced nephropathy,CIN)的预测价值。方法选取2020年11月至2021年7月在徐州医科大学附属淮安医院招募择期拟行CAG的患者。采集患者一般临床资料、血生化、血常规、血凝常规等生化指标。留取患者术前、术后血清以及术前、术后12 h、24 h、48 h尿液标本,采用酶联免疫吸附测定(enzyme-linked immunosorbent assay,ELISA)检测BI-1水平。统计分析时根据是否发生CIN分为CIN组共14例和非CIN组共112例,比较其血清及尿液中BI-1的水平,并运用ROC曲线检验BI-1水平对CAG术后发生CIN的预测价值。结果CIN组术前血清、尿液及术后12 h尿液BI-1水平低于非CIN组。ROC曲线显示,术前血清、尿液及术后12 h尿液BI-1水平曲线下面积为0.731、0.766、0.766(P<0.01)。结论在行CAG术时,术前血清、尿液及术后12 h尿液BI-1水平可作为CIN发生的预测指标。Objective To explore the predictive value of Bax inhibitor-1(BI-1)in contrastinduced nephropathy(CIN)in patients after coronary arteriography(CAG).Methods A total of 126 patients undergoing CAG were recruited from November 2020 to July 2021.General profiles,blood biochemistry and routine coagulation test were recorded.Urine samples were collected at pre-operation and12/24/48 h post-operation.Both preoperative and postoperative serum samples were assayed.BI-1level was detected by enzyme-linked immunosorbent assay(ELISA).Based upon the presence or absence of CIN,they were divided into two groups of CIN(n=14)and non-CIN(NCIN,n=112).The serum and urinary levels of BI-1 were detected.And the predictive values of serum and urine BI-1 in CIN were evaluated by receiver operating curve(ROC).Results The serum and urinary levels of BI-1 at preoperation and 12 h post-operation were lower in CIN group than those in NCIN group.ROC analysis indicated that AUCs of BI-1 level of serum and urine pre/post-operation and BI-1 level of urine 12 h postoperation were 0.731,0.766 and 0.766 respectively(P<0.01).Conclusion BI-1 level of serum and urine pre/post-operation and BI-1 level of urine 12 h post-operation may be employed as predictive parameters for CIN patients after CAG.

关 键 词：Bax抑制因子1 冠状动脉血管造影术 造影剂肾病 风险预测 

分 类 号：R541.4[医药卫生—心血管疾病] R692[医药卫生—内科学]