早产极低出生体质量儿合并及未合并新生儿坏死性小肠结肠炎出院后早期体格生长情况分析  

Analysis of Early Physical Growth after Discharge of 83 Premature Very Low Birth Weight Infants with and without Neonatal Necrotizing Enterocolitis

作　　者：高娟[1] GAO Juan(Department of Pediatric Health,Fujian Provincial Maternal and Children's Hospital,Fuzhou 350000,China)

机构地区：[1]福建省妇幼保健院儿保科,福建福州350000

出　　处：《中国医药指南》2022年第33期37-40,共4页Guide of China Medicine

摘　　要：目的 分析83例早产极低出生体质量儿合并及未合并新生儿坏死性小肠结肠炎出院后早期体格生长情况。方法 回顾性选取2015年1月至2020年1月本院早产极低出生体质量儿83例,依据合并新生儿坏死性小肠结肠炎情况分为合并组(15例)、未合并组(68例)两组,统计分析两组临床诊治资料,分析合并组患儿发病的影响因素,并统计分析两组出院后12月龄体格生长情况、营养状况、并发症发生情况、预后、舒适度、住院时间、住院费用、家长满意度。结果 合并组患儿的出生时胎龄低于未合并组(P <0.05),出生时体质量低于未合并组(P <0.05),出生后肠内喂养开始时间晚于未合并组(P <0.05),抗菌药物、易感药物应用率均高于未合并组(P <0.05),母乳喂养率低于未合并组(P <0.05),围生期窒息、败血症休克发生率均高于未合并组(P <0.05)。多因素Logistic回归分析显示,合并组患儿发病的影响因素包括应用抗菌药物、易感药物、母乳喂养、围生期窒息、败血症休克(P <0.05)。合并组患儿出院后12月龄体质量低于未合并组(P <0.05),身长短于未合并组(P <0.05)。合并组患儿出院后12月龄血清SF、Alb、Hb水平均低于未合并组(P <0.05)。合并组患儿并发症发生率40.00%(6/15)高于未合并组10.29%(7/68)(P <0.05)。两组患儿出院后严重神经发育问题、小头畸形发生率、病死率之间的差异均不显著(P> 0.05)。合并组患儿的舒适度评分低于未合并组(P <0.05),住院时间长于未合并组(P <0.05),住院费用高于未合并组(P <0.05)。合并组患儿家长满意度66.67%(10/15)低于未合并组91.18%(62/68)(P <0.05)。结论 早产极低出生体质量儿合并新生儿坏死性小肠结肠炎患儿出院后早期体格生长情况较未合并新生儿坏死性小肠结肠炎患儿差。Objective To analyze the early physical growth of 83 premature very low birth weight infants with and without neonatal necrotizing enterocolitis after discharge.Methods From January 2015 to January 2020,83 premature very low birth weight infants in our hospital were retrospectively selected,and they were divided into a combined group(15 cases)and an uncombined group(68 cases)according to the condition of neonatal necrotizing enterocolitis.two groups,the clinical diagnosis and treatment data of the two groups were statistically analyzed,the influencing factors of the incidence of children in the combined group were analyzed,and the 12 months old physical growth,nutritional status,comorbidities,prognosis,comfort,length of hospital stay,hospital costs,and parental satisfaction of the two groups after discharge were statistically analyzed.Results The gestational age at birth of the combined group was lower than that of the uncombined group(P<0.05),the birth weight was lower than that of the uncombined group(P<0.05),postnatal enteral feeding initiation was later than in the uncombined group(P<0.05),and the start time of postnatal enteral feeding was later than that of the uncombined group(P<0.05),the application rates of antibiotics and susceptible drugs were higher than those in the uncombined group(P<0.05),the breastfeeding rate was lower than that in the uncombined group(P<0.05),and the incidences of perinatal asphyxia and septic shock were higher than those in the uncombined group(P<0.05).Multivariate Logistic regression analysis showed that the risk factors of the combined group included the use of antibiotics,susceptible drugs,breastfeeding,perinatal asphyxia,and septic shock(P<0.05).The 12 months old weight of the combined group after discharge was lower than that of the uncombined group(P<0.05),and the body length was shorter than that of the uncombined group(P<0.05).The 12-month-old serum SF,Alb and Hb levels in the combined group were lower than those in the uncombined group(P<0.05).The incidence of complica

关 键 词：早产 极低出生体质量儿 新生儿坏死性小肠结肠炎 出院后 早期 体格生长 

分 类 号：R722.1[医药卫生—儿科] R574.62[医药卫生—临床医学]