盐酸替罗非班注射液联合心血管介入治疗急性心肌梗死患者的临床效果  

Clinical Effect of Tirofiban Hydrochloride Injection Combined with Cardiovascular Interventional in the Treatment of Patients with Acute Myocardial Infarction

作　　者：栾鹏娇 LUAN Pengjiao(Department of Cardiology,Central Hospital of Yingkou Economic and Technological Development Zone,the Sixth People's Hospital of Yingkou City,Yingkou 115007,China)

机构地区：[1]营口经济技术开发区中心医院(营口市第六人民医院)心内科,辽宁营口115007

出　　处：《中国医药指南》2022年第33期109-111,共3页Guide of China Medicine

摘　　要：目的 针对急性心肌梗死患者,探究该类群体应用盐酸替罗非班注射液联合心血管介入治疗的临床效果。方法 选取营口经济技术开发区中心医院于2018年5月至2019年5月收治的经临床确诊为急性心肌梗死的患者130例,按照平行对照法分为两组,均实施常规对症治疗,包括嘱患者充分休息,对于疼痛剧烈患者给予镇痛类药物,对于呼吸困难者采取呼吸机辅助呼吸,对照组65例仅单纯进行心血管介入治疗,术前为患者展开冠状动脉造影检查,根据检查结果为患者制定针对性治疗措施,由经验丰富的医师开展各项操作,观察组(65例)行盐酸替罗非班注射液联合心血管介入治疗,其中血管介入治疗与对照组相同,选取盐酸替罗非班注射液10μg/kg,经由导管引导,注入患者冠状动脉内,将注射时间控制在3 min,对两组治疗效果分析。结果 在TIMI血流分级、严重出血事件、恶性心律失常、猝死及再发急性心肌梗死发生率方面,观察组均比对照组优(P<0.05);在CD_(63)、CD_(62)P和MPA阳性表达率方面,治疗前,两组比较差异无显著性(P>0.05);与治疗后的对照组相比较,观察组上述指标均更优(P<0.05)。结论 盐酸替罗非班注射液与心血管介入联合治疗急性心肌梗死患者临床效果显著,除减轻临床病症外,还可改善心功能及血小板活化功能,有助于降低不良事件发生率。Objective To analyze the effect of tirofiban hydrochloride injection combined with cardiovascular intervention in the treatment of acute myocardial infarction.Methods In May 2018 to May 2019 in our hospital to receive a diagnosis of 130 cases of patients with acute myocardial infarction income in this experiment,based on the parallel comparison method is divided into two groups,two groups of patients were given conventional treatment,in the process of treatment,told the patient to stay in bed,and at the same time giving sedative drugs and analgesic drugs,patients take auxiliary patients breathing breathing machine,control group(65 cases)line of single cardiovascular intervention,coronary artery angiography revealed preoperative patients,according to the results of the inspection to develop a targeted treatment for patients,by experienced doctors to carry out the operations,observation group(65 cases)hydrochloride for injection with cardiovascular interventional therapy,had the vascular interventional therapy,and the control group,the same Tirofiban hydrochloride injection 10μg/kg was injected into the coronary artery of patients guided by catheter,and the injection time was controlled within 3 minutes.The therapeutic effects of the two groups were analyzed.Results The TIMI blood flow grade,severe bleeding events,malignant arrhythmia,sudden death and recurrence of acute myocardial infarction in the observation group were better than those in the control group,and the differences were significant(P<0.05).There was no significant difference in the positive expression rates of CD_(63),CD_(62)P and MPA between the observation group and the control group before treatment(P>0.05);Compared with the control group after treatment,the observation group had better(P<0.05).Conclusion Tirofiban hydrochloride injection combined with cardiovascular intervention in the treatment of acute myocardial infarction has obvious effect,in addition to reducing clinical symptoms,improving cardiac function and platelet activation function,

关 键 词：急性心肌梗死 心血管介入治疗 盐酸替罗非班 心功能 

分 类 号：R542.22[医药卫生—心血管疾病]