阿卡波糖联合盐酸二甲双胍治疗2型糖尿病的有效性分析  

Effectiveness of Acarbose Combined with Metformin Hydrochloride in the Treatment of Type 2 Diabetes

作　　者：杨英 YANG Ying(Department of Pharmacy,Zhuanghe Central Hospital,Zhuanghe 116400,China)

机构地区：[1]庄河市中心医院药剂科,辽宁庄河116400

出　　处：《中国医药指南》2022年第33期115-117,共3页Guide of China Medicine

摘　　要：目的 分析阿卡波糖联合盐酸二甲双胍治疗2型糖尿病的有效性。方法 2019年1月至2020年1月,将该期间来我院的58例2型糖尿病患者作为研究对象,按照先后入院顺序将其分为治疗组与对照组,治疗组采用阿卡波糖联合盐酸二甲双胍治疗,对照组采用盐酸二甲双胍治疗,治疗后评价临床治疗效果、不良反应发生率、血糖改善情况及生活质量。结果 治疗组治疗显效15例,治疗有效12例,治疗无效2例,治疗总有效率93.10%,对照组治疗显效13例,治疗有效8例,治疗无效8例,治疗总有效率为72.14%,两组差异显著(P <0.05)。治疗组患者1例出现排气量增多,2例出现腹胀,2例出现恶心,不良反应发生率为17.24%,对照组患者中1例出现排气量增多,1例出现腹胀,1例出现恶心,不良反应发生率为10.34%。两组不良反应比较,差异不显著(P> 0.05)。治疗前,治疗组餐后2 h血糖为(15.17±4.29)mmol/L,空腹血糖为(10.82±3.42)mmol/L,对照组餐后2 h血糖为(15.33±4.71)mmol/L,空腹血糖为(10.49±3.64)mmol/L;治疗后,治疗组餐后2 h血糖为(11.06±4.35)mmol/L,空腹血糖为(7.23±3.12)mmol/L,对照组餐后2 h血糖为(13.83±4.67)mmol/L,空腹血糖为(8.96±3.38)mmol/L,差异显著(P <0.05)。治疗组患者心理功能、物质功能、日常生活功能、社会功能评分分别为(68.32±9.21)分、(69.73±8.92)分、(63.25±8.11)分、(67.87±8.39)分,对照组分别为(57.45±7.32)分、(56.63±8.97)分、(52.78±4.56)分、(56.24±5.71)分,差异显著(P <0.05)。结论 阿卡波糖联合盐酸二甲双胍治疗对2型糖尿病患者具有显著的临床治疗效果,既能改善患者血糖情况,又能提高其生活质量,应被临床大力推广及应用。Objective To analyze the efficacy of acarbose combined with metformin hydrochloride in the treatment of type 2 diabetes.Methods From January 2019 to January 2020,58 patients with type 2 diabetes who came to our hospital during this period were selected as the research objects,and they were divided into a treatment group and a control group according to the order of admission.The treatment group was treated with acarbose combined with metformin hydrochloride treatment,the control group was treated with metformin hydrochloride,and the clinical treatment effect,incidence of adverse reactions,blood sugar improvement and quality of life were evaluated after treatment.Results In the treatment group,15 cases were markedly effective,12 cases were effective,2 cases were ineffective,and the total effective rate was 93.10%.In the control group,13 cases were markedly effective,8 cases were effective,and 8 cases were ineffective,with a total effective rate of 72.14%,the difference between the two groups was significant(P<0.05).In the treatment group,1 patient had increased exhaust volume,2 patients had abdominal distension,and 2 patients had nausea.The incidence of adverse reactions was 17.24%.In the control group,1 patient had increased exhaust volume,1 patient had abdominal distension,and 1 patient had nausea,the incidence of adverse reactions was 10.34%.No siqnificant difference in adverse reactions between the two groups(P>0.05).Before treatment,the 2 h postprandial blood glucose in the treatment group was(15.17±4.29)mmol/L,and the fasting blood glucose was(10.82±3.42)mmol/L,while the 2 h postprandial blood glucose in the control group was(15.33±4.71)mmol/L,and the fasting blood glucose was(10.49±3.64)mmol/L,after treatment,the 2h postprandial blood glucose in the treatment group was(11.06±4.35)mmol/L,the fasting blood glucose was(7.23±3.12)mmol/L,and the 2 h postprandial blood glucose in the control group was(13.83±4.67)mmol/L,fasting blood glucose was(8.96±3.38)mmol/L,the difference was significant(P<0.05).The s

关 键 词：阿卡波糖 盐酸二甲双胍 2型糖尿病 不良反应 治疗效果 

分 类 号：R587.1[医药卫生—内分泌]