Comment on“Structural basis for the severe adverse interaction of sofosbuvir and amiodarone on L-type Cav channels”  

作　　者：Guo-Liang Zheng 

机构地区：[1]Department of Gastric Surgery,Cancer Hospital of China Medical University(Liaoning Cancer Hospital and Institute),Shenyang 110042,China

出　　处：《TMR Pharmacology Research》2022年第4期19-21,共3页TMR药理学研究

摘　　要：A breakthrough article by Yao et al.(2022),published in the journal Cell,performed systematic cryo-electron microscopic structure analysis of Cav1.1 and Cav1.3 treated with AMIO or SOF alone or SOF/MNI-1 combined with AMIO[1].DDI between the antiviral drug SOF and the antiarrhythmic drug AMIO have been reported to cause severe slowing of heartbeat rate[2].AMIO is a multichannel antagonist.SOF and its analogue MNI-1 have been reported to enhance the inhibitory effect of AMIO on calcium ions in cardiomyocytes and may inhibit L-type Cav channels,but the molecular mechanism remains unclear[3,4].

关 键 词：breakthrough journal INTERACTION 

分 类 号：S85[农业科学—兽医学]