Application of network pharmacology in uncovering the biological basis of using the Banxia Baizhu Tianma decoction for hypertension treatment  

作　　者：Yong Yang Jia-Ru Wang Rui-Zhu Jiang Yang Zheng Tie-Jian Zhao Ying Zhang 

机构地区：[1]College of Nursing,Guangxi University of Chinese Medicine,Nanning 530200,China [2]Faculty of Chinese Medicine Science,Guangxi University of Chinese Medicine,Nanning 530222,China [3]Department of Physiology,College of Basic Medicine,Guangxi University of Chinese Medicine,Nanning 530200,China

出　　处：《TMR Pharmacology Research》2022年第4期31-39,共9页TMR药理学研究

基　　金：This work was supported by the Funding for Key Projects of Natural Science Foundation of Guangxi(No.2013GXNSFDA278001);Guangxi Planning of Philosophy and Social Sciences(No.15BRK002,20FGL024);2020 Guangxi University young and middle-aged teachers'basic research ability improvement project of Guangxi Education and research No.1,2020(No.2020KY07048);2019 Guangxi University of Traditional Chinese Medicine University scientific research project of Traditional Chinese Medicine No.6,2019(No.2019MS009);2019 Guangxi University of Traditional Chinese Medicine University scientific research project of Traditional Chinese Medicine No.1,2019(No.2019KY1084);2022 Guangxi University of Traditional Chinese Medicine College Students'Innovation and Entrepreneurship Training Program(No.S202210600119)。

摘　　要：Background:The Banxia Baizhu Tianma decoction(BBTD)is widely used in the clinical treatment of hypertension and has definite curative effects.However,its active ingredients and mechanism of action in hypertension treatment are still unknown.In this study,network pharmacology was used to elucidate the potential antihypertensive mechanism of BBTD.Methods:The active ingredients and targets of BBTD were screened in the pharmacological database of the Chinese medicine system.The targets that are related to hypertension were obtained from the Online Mendelian Inheritance in Man(OMIM),Drugbank,and Genecards databases.The String database was used to analyze the prevention and treatment of hypertension by BBTD.The interaction of important targets was assessed,and the related network data was visualized using the Cytoscape software.The OmicShare platform was employed in conducting enrichment analyses of gene functions and pathways of important targets,in addition to evaluating the relationship between important targets and the phenotype of hypertension.Molecular docking of the main active ingredients with important targets was also assessed.Results:In this study,194 main active ingredients and 616 targets of BBTD were screened,and 5,819 related targets that are closely related to hypertension were unearthed.A total of 445 BBTD key targets for the treatment of hypertension were obtained,along with 73 core targets from performed network topology and module analysis on the key targets.The enrichment analyses of GO and KEGG showed that oxidative stress,HIF-1 signal,IL-17 signal,and TNF signal play a vital role in hypertension.Molecular docking studies have revealed that the main biologically active components can be combined with key targets quite well.Conclusion:The potential mechanism of BBTD in treating hypertension involves many components,targets,and pathways.Some of the potential targets for the prevention and treatment of hypertension are ESR1,MAPK,TP53,TNF,and MMP9.These findings provide a reference for further researc

关 键 词：Banxia Baizhu Tianma decoction HYPERTENSION network pharmacology oxidative stress 

分 类 号：R54[医药卫生—心血管疾病]