Influence of buccal acupuncture on analgesic effect,immune indicators,and expression of Survivin and Livin proteins in patients with advanced-stage primary liver cancer  

颊针对原发性中晚期肝癌患者镇痛效应、免疫指标及Survivin、Livin蛋白表达的影响

作　　者：LIN Zhiguang SU Shengxian XIE Xiaoli YANG Yuanfeng DONG Qinglong KONG Xiehe 林志光;苏圣贤;解小丽;杨源锋;董庆龙;孔谐和(Department of Pain Medicine,Zhongshan People's Hospital,Zhongshan 528400,China;Department of Anesthesiology,Graduate School of Guangzhou Medical University,Zhongshan 528400,China;Department of Anesthesia and Surgery,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510120,China;不详)

机构地区：[1]Department of Pain Medicine,Zhongshan People's Hospital,Zhongshan 528400,China [2]Department of Anesthesiology,Graduate School of Guangzhou Medical University,Zhongshan 528400,China [3]Department of Anesthesia and Surgery,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510120,China [4]不详

出　　处：《Journal of Acupuncture and Tuina Science》2022年第5期383-391,共9页针灸推拿医学（英文版）

基　　金：广东省医学科学技术重点研究基金,No.2018YS1548。

摘　　要：Objective To investigate the effects of buccal acupuncture on analgesia,immune indicators,and expression levels of Survivin and Livin proteins in patients with advanced-stage primary liver cancer.Methods Eighty patients with advanced-stage primary liver cancer were selected and divided into control and treatment groups according to the difference in treatment modalities,with 40 patients in each group.The control group received transcatheter arterial chemoembolization(TACE),and the treatment group received buccal acupuncture in addition to TACE.The recent efficacy,analgesic effect,liver function,serum tumor markers,Survivin and Livin protein expression levels in liver cancer tissue,and immune indexes were analyzed and compared between the two groups.Results The objective response rate(ORR)and disease control rate(DCR)of the treatment group were 37.5%and 77.5%,respectively,which were significantly higher than those of the control group(22.5%and 52.5%),and the recent efficacy of the treatment group was significantly better than that of the control group(P<0.05).The onset of analgesia in the treatment group was significantly faster than that in the control group(P<0.05),the duration of analgesia was significantly longer than that in the control group(P<0.05),and the numeric rating scale(NRS)score of pain after treatment was significantly lower than that in the control group(P<0.05).In the treatment group,the aspartate aminotransferase(AST),alanine aminotransferase(ALT),and albumin/globulin(A/G)were significantly lower than those in the control group(P<0.05),and the serum levels of alpha-fetoprotein(AFP),alpha-L-fucosidase(AFU),and carcinoembryonic antigen(CEA)were significantly lower than those in the control group(P<0.05),and the expression levels of Survivin and Livin in liver cancer tissue were significantly lower than those in the control group(P<0.05);CD4^(+)and CD4^(+)/CD8+in the treatment group were significantly higher than those in the control group,and CD8+was significantly lower than that in the control gr目的探讨颊针对原发性中晚期肝癌患者镇痛效应、免疫指标及Survivin、Livin蛋白表达的影响.方法选取80例原发性中晚期肝癌患者,根据治疗方式的差异,将其分为对照组与治疗组,每组40例.对照组接受经导管肝动脉栓塞化疗(TACE),治疗组在此基础上加用颊针疗法.对两组患者近期疗效、镇痛效应、肝功能、血清肿瘤标志物、肝癌组织Survivin、Livin蛋白表达水平及免疫指标进行分析比较.结果治疗组客观缓解率(ORR)、疾病控制率(DCR)分别为37.5%和77.5%,明显高于对照组的22.5%和52.5%,治疗组近期疗效明显优于对照组(P<0.05).治疗组镇痛起效时间明显短于对照组(P<0.05),镇痛持续时间明显长于对照组(P<0.05),治疗后疼痛数字评分法(NRS)评分明显低于对照组(P<0.05).治疗后,治疗组谷草转氨酶(AST)、谷丙转氨酶(ALT)、白蛋白与球蛋白比值(A/G)均明显低于对照组(P<0.05),血清肿瘤标志物甲胎蛋白(AFP)、α-L-岩藻糖苷酶(AFU)、癌胚抗原(CEA)水平均明显低于对照组(P<0.05),肝癌组织Survivin、Livin蛋白表达水平均明显低于对照组(P<0.05);治疗后,治疗组CD4^(+)、CD4^(+)/CD8^(+)比值均明显高于对照组,CD8^(+)明显低于对照组(P<0.05).结论颊针可以减轻原发性中晚期肝癌患者疼痛程度及肝功能损伤,降低血清肿瘤标志物水平,其作用机制可能与下调肝癌组织Survivin、Livin蛋白表达水平,调节机体免疫功能有关.

关 键 词：Acupuncture Therapy Buccal Acupuncture Liver Neoplasms Acupuncture Analgesia Immune Function Liver Function Tests Biomarkers Tumor SURVIVIN 

分 类 号：R246.5[医药卫生—针灸推拿学]