中医药对慢性阻塞性肺疾病TGF-β信号通路影响的研究进展  

Research progress on effect of traditional Chinese medicine on TGF-βsignal pathway of COPD

作　　者：陈云坤(综述) 王杰[1] 李秀华[1] 张文斌(审校)[1] CHEN Yunkun;WANG Jie;LI Xiuhua;ZHANG Wenbin(Department of Respiratory and Critical Care Medicine,Chongqing Municipal Hospital of Traditional Chinese Medicine,Chongqing 400021,China)

机构地区：[1]重庆市中医院呼吸与危重症医学科,400021

出　　处：《重庆医学》2022年第23期4093-4099,共7页Chongqing medicine

基　　金：重庆市自然科学基金面上项目(cstc2020jcyj-msxmX1084);成都中医药大学2020年度“杏林学者”医院专项(YYZX2020055);重庆市名老中医药专家李秀华传承工作室建设项目(渝中医[2020]20号)。

摘　　要：转化生长因子-β(TGF-β)属于一组新近发现的调节细胞生长和分化的细胞生长因子,可以调节免疫应答、细胞增殖与分化、组织修复与细胞外基质合成和凋亡,在慢性阻塞性肺疾病发病机制中处于重要环节。因此,通过调控TGF-β信号通路,减少或延缓慢性阻塞性肺疾病气道重塑,将成为临床治疗慢性阻塞性肺疾病的重要方法之一。该文介绍了TGF-β信号通路在慢性阻塞性肺疾病中的作用及中医药调控TGF-β信号通路减少或延缓慢性阻塞性肺疾病气道重塑的研究进展,为中医药预防及治疗慢性阻塞性肺疾病提供重要的理论依据及开辟新的方向。TGF-βbelongs to a newly discovered group of cell growth factors that regulate the cell growth and differentiation,which can regulate the immune response,cell proliferation and differentiation,tissue repair,extracellular matrix synthesis and apoptosis,and is at an important link in the pathogenesis of chronic obstructive pulmonary disease(COPD).Therefore,by regulating TGF-βsignal pathway,reducing or delaying airway remodeling of COPD will become one of the important methods of clinical treatment of COPD.This paper introduces the role of TGF-βsignaling pathway in COPD and the research progress of traditional Chinese medicine(TCM)regulation and control of TGF-βsignaling pathway to reduce or delay the airway remodeling of COPD,which provides an important theoretical basis and opens up a new direction for prevention and treatment of COPD.

关 键 词：慢性阻塞性肺疾病 转化生长因子-Β 信号通路 中药 

分 类 号：R563[医药卫生—呼吸系统]