职业性噪声所致高频听力损失与高血压发生风险的病例对照研究  

A case-control study of occupational noise exposure induced high-frequency hearing loss and the risk of hypertension

作　　者：刘霞 王炜[2] 孙纳[2] 周建伟[1] 李春平[2] Liu Xia;Wang Wei;Sun Na;Zhou Jianwei;Li Chunping(Department of Occupational and Environmental Health,School of Public Health Key Laboratory of Modern Toxicology of the Ministry of Education Nanjing Medical University,Nanjing 210029,China Wuxi Center for Disease Control and Prevention,Nanjing Medical University,Wuxi 214023,China)

机构地区：[1]南京医科大学公共卫生学院职业与环境卫生学系,现代毒理学教育部重点实验室,南京210029 [2]南京医科大学附属无锡疾病预防控制中心,无锡214023

出　　处：《中华劳动卫生职业病杂志》2022年第10期746-750,共5页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：无锡市卫健委中青年拔尖人才资助计划;无锡市卫健委科研项目(M202169)。

摘　　要：目的探讨职业性噪声所致高频听力损失与高血压发生风险之间的关系。方法于2020年3月,采用病例对照研究,选择无锡市2019年所有参加职业健康体检的噪声作业工人作为研究对象(共95432人),出现高血压为病例组,血压正常者作定义为对照组,根据听力阈值分为非高频听力损失组(<40 dB)和高频听力损失组(≥40 dB)。用单因素统计方法和二元logistic回归评估高频听力损失与高血压患病风险之间的关系。用分层分析比较不同年龄与工龄的高频听力损失工人患高血压病的风险。结果对照组和高血压组工人性别、年龄、工龄、企业规模、经济类型、高频听力损失差异均有统计学意义(P<0.05)。二元logistic回归分析显示,在调整了性别、年龄、工龄、企业规模、经济类型后,高频听力损失组高血压患病的风险仍增加(OR=1.062,95%CI=1.007~1.121,P=0.027)。20~39岁与40~59岁年龄组高频听力损失者高血压患病风险高于非高频听力损失者(OR=1.536,95%CI=1.353~1.743;OR=1.179,95%CI=1.111~1.1250,P<0.05);<5年、5~9年、10~14年、15~19年和≥20年工龄组高频听力损失者高血压患病风险高于非高频听力损失者(OR=1.926,95%CI=1.007~1.121;OR=1.635,95%CI=1.478~1.810;OR=1.312,95%CI=1.167~1.474;OR=1.445,95%CI=1.238~1.686;OR=1.235,95%CI=1.043~1.463,P<0.05)。结论职业性噪声引起的高频听力损失与高血压患病风险有一定的关系,且不同年龄与工龄高频听力损失者高血压患病风险不同。Objective To investigate the relationship between high frequency hearing loss caused by occupational noise and the risk of hypertension.Methods In March 2020,a case-control study was conducted.All noise exposed workers who participated in occupational health examination in Wuxi City in 2019 were selected as the study subjects(95432 cases in total).The hypertension group was defined as the case group,and the normotensive group was defined as the control group.According to the hearing threshold,they were divided into the non high frequency hearing loss group(<40 dB)and the high frequency hearing loss group(≥40 dB).Univariate statistical method and binary logistic regression were used to evaluate the relationship between high-frequency hearing loss and hypertension risk.Stratified analysis was used to compare the risk of hypertension among workers with high-frequency hearing loss of different ages and length of service.Results There were significant differences in gender,age,length of service,enterprise scale,economic type and high-frequency hearing loss between control group and hypertension group(P<0.05).Binary logistic regression analysis showed that after adjusting for gender,age,length of service,enterprise scale and economic type,the risk of hypertension in the high-frequency hearing loss group was still increased(OR=1.062,95%CI:1.007~1.121,P=0.027).The risk of hypertension in high-frequency hearing loss patients was higher than that in non high-frequency hearing loss patients in 20-39 years old and 40-59 years old age groups(OR=1.536,95%CI:1.353~1.743;OR=1.179,95%CI:1.111~1.250;P<0.05).The risk of hypertension in high-frequency hearing loss patients in<5years,5-9years,10-14 years,15-19 years and≥20 years working age groups were higher than that in non high-frequency hearing loss groups(OR=1.926,95%CI=1.007-1.121;OR=1.635,95%CI=1.478-1.810;OR=1.312,95%CI=1.167-1.474;OR=1.445,95%CI=1.238-1.686;OR=1.235,95%CI=1.043-1.463;P<0.05).Conclusion There is a certain relationship between high-frequency hearing loss c

关 键 词：噪声 职业性 听力损失 高血压 病例对照研究 

分 类 号：R135.8[医药卫生—劳动卫生] R544.1[医药卫生—公共卫生与预防医学]