藿香正气丸(浓缩丸)HPLC指纹图谱  

Huoxiang Zhengqi Pills(Concentrated Pills)HPLC Fingerprint

作　　者：王孟颖 孙福英 赵雯 饶毅[3] 万林春 WANG Mengying;SUN Fuying;ZHAO Wen;RAO Yi;WAN Linchun(Jiangxi Institute for Drug Control,NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Patent Medicine,Jiangxi Provincial Engineering Research Center of Drug and Medical Device Quality,Nanchang Jiangxi 330029,China;Jiangxi Cancer Hospital,Nanchang Jiangxi 330029,China;Jiangxi University of Traditional Chinese Medicine,Nanchang Jiangxi 330004,China)

机构地区：[1]江西省药品检验检测研究院,国家药品监督管理局中成药质量评价重点实验室,江西省药品与医疗器械质量工程技术研究中心,江西南昌330029 [2]江西省肿瘤医院,江西南昌330029 [3]江西中医药大学,江西南昌330004

出　　处：《药品评价》2022年第19期1172-1176,共5页Drug Evaluation

基　　金：江西省药品监督管理局课题(2019JS10)。

摘　　要：目的:建立藿香正气丸(浓缩丸)的HPLC指纹图谱。方法:采用Agilent Zorbax C18色谱柱,流动相为乙腈(A)-0.2%甲酸溶液(B),梯度洗脱,检测波长为270 nm,使用中药色谱指纹图谱相似度评价系统进行相似度评价,并对藿香正气丸(浓缩丸)指纹图谱进行了研究。结果:建立了藿香正气丸(浓缩丸)的HPLC指纹图谱,标定了13个共有峰,并指认出9个成分。结论:该方法稳定可靠,可用于藿香正气丸(浓缩丸)的质量控制。Objective:To establish a HPLC fingerprint of huoxiang zhengqi pills(concentrated pills).Methods:Agilent Zorbax C18 chromatographic column was used,the mobile phase was acetonitrile(A)-0.2%formic acid solution(B),gradient elution,and the detection wavelength was 270 nm.The similarity evaluation system of chromatographic fingerprints of traditional Chinese medicine was used to evaluate the similarity,and the fingerprint of huoxiang zhengqi pills(concentrated pills)was studied.Results:HPLC fingerprint of huoxiang zhengqi pills(concentrated pills)was established,13 common peaks were calibrated,and 9 components were identified.Conclusion:The method is stable and reliable,and can be used for the quality control of huoxiang zhengqi pills(concentrated pills).

关 键 词：藿香正气丸(浓缩丸) 指纹图谱 相似度评价 HPLC 

分 类 号：O657.72[理学—分析化学] R286.0[理学—化学]