熊去氧胆酸联合丁二磺酸腺苷蛋氨酸治疗妊娠期肝内胆汁淤积综合征  

Ursodeoxycholic Acid Combined with Ademetionine 1,4-Butanedisulfonate in the Treatment of Intrahepatic Cholestasis Syndrome During Pregnancy

作　　者：周鹏 ZHOU Peng(Yichun Maternal and Child Health Care Hospital,Yichun Jiangxi 336000,China)

机构地区：[1]宜春市妇幼保健院,江西宜春336000

出　　处：《药品评价》2022年第19期1177-1180,共4页Drug Evaluation

基　　金：宜春市科技计划项目(2022ZDJH6056)。

摘　　要：目的:探讨熊去氧胆酸联合丁二磺酸腺苷蛋氨酸治疗妊娠期肝内胆汁淤积综合征的临床效果。方法:纳入2021年6月至2022年1月宜春市妇幼保健院接诊的60例妊娠期肝内胆汁淤积综合征患者作为本次的研究对象。按照随机数字表法分为两组,每组30例。对照组给予熊去氧胆酸+基础治疗,观察组在此基础上加用丁二磺酸腺苷蛋氨酸治疗。比较两组患者治疗前后血清肝功能指标[总胆红素(TBIL)、总胆汁酸(TBA)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)]检测结果变化情况以及不良妊娠情况的发生率。结果:两组治疗1周及2周后肝功能各项指标检测结果均低于同组治疗前(P<0.05);观察组治疗1周及2周后肝功能各项指标检测结果均低于对照组同时期(P<0.05);观察组不良妊娠情况低于对照组(P<0.05);两组干预前瘙痒症状评分对比,差异无统计学意义(P>0.05);对照组干预后瘙痒症状评分低于干预前(P<0.05);观察组干预后瘙痒症状评分低于干预前和对照组(P<0.05)。观察组干预后进展成重度妊娠期肝内胆汁淤积综合征的产妇为1例,对照组进展成重度妊娠期肝内胆汁淤积综合征的产妇为5例,两组数据间对比,差异有统计学意义(P<0.05)。结论:熊去氧胆酸联合丁二磺酸腺苷蛋氨酸治疗妊娠期肝内胆汁淤积综合征疗效显著,能够有效改善患者肝功能及妊娠结局。Objective:To investigate the clinical effect of ursodeoxycholic acid combined with ademetionine 1,4-butanedisulfonate in the treatment of intrahepatic cholestasis syndrome during pregnancy.Methods:60 patients with intrahepatic cholestasis syndrome during pregnancy treated in Yichun Maternal and Child Health Care Hospital,from June 2021 to January 2022 were included in this study.According to random number table method,they were divided into two groups,30 cases in each group.The control group was given ursodeoxycholic acid plus basic treatment,and the observation group was additionally treated with ademetionine 1,4-butanedisulfonate.The changes of serum liver function indexes[total bilirubin(TBIL),total bile acid(TBA),alanine aminotransferase(ALT),aspartic aminotransferase(AST)]and the incidence of adverse pregnancy were compared between 2 groups before and after treatment.Results:The results of liver function indexes at 1 and 2 weeks after treatment were lower than those before treatment(P<0.05).The results of liver function indexes in the observation group at 1 and 2 weeks after treatment were significantly lower than those in the control group at the same period(P<0.05).Adverse pregenancy in the observation group was lower than that in the control group(P<0.05).There was no significant difference in the incidence of intrauterine fetal death between the two groups(P>0.05).There was no significant difference in pruritus symptom score between the two groups before intervention(P>0.05).Pruritus symptom score of control group after intervention was lower than before intervention.Pruritus symptom score of observation group after intervention was lower than that before intervention and control group(P<0.05).In the observation group,1 case was developed into severe intrahepatic cholestasis syndrome of pregnancy after intervention,and 5 cases were developed into severe intrahepatic cholestasis syndrome of pregnancy after treatment in the control group,there was significant difference between the data(P<0.05).Conclusion:

关 键 词：妊娠并发症 胆汁淤积 肝内 熊去氧胆酸 丁二磺酸腺苷蛋氨酸 肝功能 妊娠结局 

分 类 号：R714.255[医药卫生—妇产科学]