Morphological changes in Parkinson's disease based on magnetic resonance imaging:A mini-review of subcortical structures segmentation and shape analysis  

作　　者：Jin-Huan Deng Han-Wen Zhang Xiao-Lei Liu Hua-Zhen Deng Fan Lin 

机构地区：[1]Department of Radiology,The First Affiliated Hospital of Shenzhen University,Health Science Center,Shenzhen Second People’s Hospital,Shenzhen 518035,Guangdong Province,China

出　　处：《World Journal of Psychiatry》2022年第12期1356-1366,共11页世界精神病学杂志

基　　金：Supported by the Guangdong Basic and Applied Basic Research Foundation,No.2021A1515220131;Youth Exploration Fund of Shenzhen Health Economics Society,No.202211;and Clinical Research Project of Shenzhen Second People’s Hospital,No.223375022.

摘　　要：Parkinson's disease(PD)is a neurodegenerative disorder caused by the loss of dopaminergic neurons in the substantia nigra,resulting in clinical symptoms,including bradykinesia,resting tremor,rigidity,and postural instability.The pathophysiological changes in PD are inextricably linked to the subcortical structures.Shape analysis is a method for quantifying the volume or surface morphology of structures using magnetic resonance imaging.In this review,we discuss the recent advances in morphological analysis techniques for studying the subcortical structures in PD in vivo.This approach includes available pipelines for volume and shape analysis,focusing on the morphological features of volume and surface area.

关 键 词：Parkinson's disease Dopaminergic neurons Magnetic resonance imaging Substantia nigra MORPHOLOGICAL 

分 类 号：R445.2[医药卫生—影像医学与核医学] R742.5[医药卫生—诊断学]