Amyloidβ-related angiitis of the central nervous system occurring after COVID-19 vaccination:A case report  

作　　者：Mayuki Kizawa Yasushi Iwasaki 

机构地区：[1]Department of Pathology,Tokai Central Hospital,Kakamigahara 504-8601,Japan [2]Bulletin of The Institute for Medical Science of Aging,Aichi Medical University,Nagakute City 480-1195,Japan

出　　处：《World Journal of Clinical Cases》2022年第34期12617-12622,共6页世界临床病例杂志

摘　　要：BACKGROUND Although coronavirus disease 2019(COVID-19)vaccines have been effective in controlling the COVID-19 pandemic,a variety of post-vaccination neurological complications have been reported worldwide.Amyloidβ-related angiitis(ABRA)is a rare neurological disease.The underlying cause of ABRA is unknown,but several studies suggest that it is caused by an excessive immune response to amyloid-βdeposited in blood vessels.In addition,limited attention has been paid to potential triggers of ABRA,such as infection or vaccination.CASE SUMMARY We report a case of ABRA that developed 2 wk after COVID-19 vaccination.A 75-year-old woman developed a frontal headache after receiving a second dose of COVID-19 BNT162b2 vaccine(Pfizer-BioNTech).Diffusion-weighted magnetic resonance imaging(DW-MRI)of the head showed abnormal hyperintensity,suggesting cerebral infarctions in the left parietal and occipital lobes.We diagnosed her condition as ABRA based on a brain biopsy.We administered steroid pulse therapy and the patient’s symptoms and DW-MRI abnormalities improved.This case had a good outcome due to prompt diagnosis and treatment.CONCLUSION We report a case of ABRA that may have been triggered by COVID-19 vaccination.

关 键 词：Amyloidβ-related angiitis COVID-19 Neurological complications VACCINATION Case report 

分 类 号：R186[医药卫生—流行病学] R741[医药卫生—公共卫生与预防医学]