Time trends in antithrombotic therapy prescription patterns: Realworld monocentric study in hospitalized patients with atrial fibrillation  

作　　者：Maurizio Giuseppe Abrignani Alberto Lombardo Annabella Braschi NicolòRenda Vincenzo Abrignani Renzo M Lombardo 

机构地区：[1]Operative Unit of Cardiology,Department of Medicine,S.Antonio Abate Hospital of Trapani,ASP Trapani,Trapani 91100,Trapani,Italy [2]Department of Psychology,Educational Science and Human Movement,University of Palermo,Palermo 90100,Palermo,Italy [3]Department of Medicine and Surgery,University of Parma,Parma 43100,Parma,Italy [4]Operative Unit of Internal Medicine with Stroke Care,Department of Health Promotion,Mother and Child Care,Internal Medicine and Medical Specialties(ProMISE)"G.D'Alessandro",University of Palermo,Palermo 90100,Palermo,Italy [5]Department of Cardiology,Operative Unit of Cardiology,Department of Medicine,S.Antonio Abate Hospital of Trapani,Trapani 91100,Trapani,Italy

出　　处：《World Journal of Cardiology》2022年第11期576-598,共23页世界心脏病学杂志（英文版）（电子版）

摘　　要：BACKGROUND Since 2010,the European Society of Cardiology has extended prescription criteria for oral antithrombotic therapy(OAT)in atrial fibrillation(AF).Direct oral anticoagulants(DOACs)were upgraded from an IIAa recommendation in 2012 to an IA in 2016.In real-world scenarios,however,OAC prescription is still suboptimal,mainly for DOACs.AIM To evaluate OAT temporal prescription patterns in a cohort of patients hospitalized with AF in a Cardiology Department.METHODS A retrospective observational study was conducted on a cohort of hospitalized patients in a secondary setting(Trapani,Italy)from 2010 to 2021 with AF as the main or secondary diagnosis.For 4089 consecutive patients,the variables extracted from the Cardiology department database were:Sex,age,time of hospitalization,antithrombotic therapy(warfarin,acenocoumarol,apixaban,dabigatran,edoxaban,rivaroxaban,aspirin,clopidogrel,other antiplatelet agents,low molecular weight heparin,and fondaparinux),diagnosis at discharge and used resources.Basal features are presented as percentage values for categorized variables and as mean+/-SD for categorized once.RESULTS From January 1st,2010 to October 6th,2021,25132 patients were hospitalized in our department;4089(16.27%,mean age 75.59+/-10.82)were discharged with AF diagnosis;of them,2245 were males(54.81%,mean age 73.56+/-11.45)and 1851 females(45.19%,mean age 78.06+/-9.47).Average length of stay was 5.76+/-4.88 days;154 patients died and 88 were moved to other Departments/Structures.AF was the main diagnosis in 899 patients(21.94%).The most frequent main diagnosis in patients with AF was acute myocardial infarction(1973 discharges,48.19%).The most frequent secondary cardiac diagnosis was chronic coronary syndrome(1864 discharges,45.51%),and the most frequent secondary associated condition was arterial hypertension(1010 discharges,24.66%).For the analysis of antithrombotic treatments,the final sample included 3067 patients,after excluding in-hospital deaths,transferred out or self-discharged patients,as well as dis

关 键 词：Atrial fibrillation Antithrombotic agents Time series WARFARIN Direct-acting oral anticoagulants ASPIRIN 

分 类 号：R541.75[医药卫生—心血管疾病]