曼月乐与地屈孕酮对围绝经期异常子宫出血的疗效分析  

Analysis of the efficacy of Mirena and dydrogesterone in the treatment of perimenopausal abnormal uterine bleeding

作　　者：袁智英 YUAN Zhi-ying(Jingjiang Maternal and Child Health Hospital,Jingjiang 214500,China)

机构地区：[1]靖江市妇幼保健院,214500

出　　处：《中国现代药物应用》2022年第20期24-27,共4页Chinese Journal of Modern Drug Application

摘　　要：目的比较分析左炔诺孕酮宫内节育系统(商品名:曼月乐)与地屈孕酮治疗围绝经期异常子宫出血(AUB)的效果。方法98例围绝经期排卵障碍性异常子宫出血患者,根据治疗方法的不同将其分为A组(56例)和B组(42例)。A组给予地屈孕酮片治疗,B组于下次月经来潮第5~7天宫内放置曼月乐。比较两组患者异常子宫出血症状缓解时间和消失时间、不良反应发生情况以及治疗前后子宫内膜厚度、月经失血图(PBAC)评分。结果B组患者异常子宫出血症状缓解时间与消失时间分别为(25.32±5.01)、(37.25±8.47)h,均短于A组的(42.26±6.15)、(59.46±9.65)h,差异均具有统计学意义(P<0.05)。治疗1、3、6个月后,两组患者子宫内膜厚度均小于治疗前,且B组患者治疗3、6个月后的子宫内膜厚度分别为(8.40±1.72)、(6.44±1.39)mm,均小于A组的(10.05±1.14)、(7.98±1.56)mm,差异均具有统计学意义(P<0.05)。治疗后,两组患者PBAC评分均低于治疗前,且B组患者PBAC评分(46.52±12.33)分低于A组的(70.83±9.72)分,差异均具有统计学意义(P<0.05)。B组不良反应发生率11.90%低于A组的28.58%,差异具有统计学意义(P<0.05)。结论在围绝经期异常子宫出血治疗中,曼月乐治疗效果显著,可在短时间内控制出血,减少出血量,且安全性高,值得推广应用。Objective To compare and analyze the effect of levonorgestrel intrauterine system(trade name:Mirena)and dydrogesterone in the treatment of perimenopausal abnormal uterine bleeding(AUB).Methods A total of 98 patients with perimenopausal abnormal uterine bleeding due to ovulatory dysfunction were divided into group A(56 cases)and group B(42 cases)according to different treatment methods.Group A was treated with dydrogesterone tablets and group B was treated with intrauterine placement of Mannitol on the 5th to 7th day of the next menstrual period.Both groups were compared in terms of remission time and disappearance time of abnormal uterine bleeding symptoms,occurrence of adverse reactions,endometrial thickness and pictorial blood loss assessment chart(PBAC)score before and after treatment.Results The remission time and disappearance time of abnormal uterine bleeding symptoms of group B were(25.32±5.01)and(37.25±8.47)h,which were shorter than(42.26±6.15)and(59.46±9.65)h of group A,and the differences were all statistically significant(P<0.05).After 1,3 and 6 months of treatment,the endometrial thickness of the two groups was lower than that of this group before treatment;the endometrial thickness of group B after 3 and 6 months of treatment were(8.40±1.72)and(6.44±1.39)mm,which were less than(10.05±1.14)and(7.98±1.56)mm of group A;the differences were all statistically significant(P<0.05).After treatment,the PBAC scores of the two groups were lower than those of this group before treatment,and the PBAC score(46.52±12.33)points of group B was lower than(70.83±9.72)points of group A,and the differences were all statistically significant(P<0.05).The incidence of adverse reactions 11.90%in group B was lower than 28.58%in group A,and the difference was statistically significant(P<0.05).Conclusion Mirena has significant therapeutic effect in the treatment of perimenopausal abnormal uterine bleeding,which can control the bleeding in a short time,reduce the amount of bleeding,and has high safety.It is worthy of p

关 键 词：围绝经期 异常子宫出血 地屈孕酮 左炔诺孕酮宫内节育系统 疗效 安全性 

分 类 号：R711.52[医药卫生—妇产科学]