无创呼吸机联合吗啡治疗急性左心衰的疗效观察  

Observation on the efficacy of non-invasive ventilator combined with morphine in the treatment of acute left heart failure

作　　者：张文娟 ZHANG Wen-juan(Second Department of Cardiology,Dandong First Hospital,Dandong 118000,China)

机构地区：[1]丹东市第一医院心内二科,118000

出　　处：《中国现代药物应用》2022年第20期125-127,共3页Chinese Journal of Modern Drug Application

摘　　要：目的观察无创呼吸机联合吗啡治疗急性左心衰的临床疗效。方法80例急性左心衰患者,依据随机法将患者分为观察组与对照组,各40例。对照组采用无创呼吸机通气治疗,观察组采用无创呼吸机联合吗啡治疗。对比两组治疗效果、不良反应发生情况及治疗前后临床指标[平均动脉压(MAP)、左室射血分数(LVEF)、心率(HR)、呼吸频率(RR)、动脉血二氧化碳分压(PaCO_(2))]变化情况。结果观察组治疗总有效率95.00%高于对照组的70.00%,差异有统计学意义(P<0.05)。两组不良反应发生率对比,差异无统计学意义(P>0.05)。治疗后,观察组MAP(85.50±8.50)mm Hg(1 mm Hg=0.133 kPa)、LVEF(55.30±5.40)%、HR(88.50±9.50)次/min、RR(15.90±1.50)次/min、PaCO_(2)(35.50±3.30)mm Hg均优于对照组的(97.90±8.80)mm Hg、(42.30±3.50)%、(100.50±9.50)次/min、(18.90±2.20)次/min、(42.50±6.60)mm Hg,差异均有统计学意义(P<0.05)。结论无创呼吸机联合吗啡治疗急性左心衰可有效改善患者临床症状,提升治疗效果,安全性高。Objective To observe the clinical efficacy of non-invasive ventilator combined with morphine in the treatment of acute left heart failure.Methods A total of 80 patients with acute left heart failure were randomly divided into observation group and control group,with 40 cases in each group.The control group was treated with non-invasive ventilator ventilation,and the observation group was treated with non-invasive ventilator combined with morphine.Both groups were compared in terms of therapeutic effect,occurrence of adverse reactions,and changes of clinical indicators[mean arterial pressure(MAP),left ventricular ejection fraction(LVEF),heart rate(HR),respiratory rate(RR),arterial partial pressure of carbon dioxide(PaCO_(2))]before and after treatment.Results The total effective rate 95.00%of the observation group was higher than 70.00%of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).After treatment,the MAP(85.50±8.50)mm Hg(1 mm Hg=0.133 kPa),LVEF(55.30±5.40)%,HR(88.50±9.50)times/min,RR(15.90±1.50)times/min,PaCO_(2)(35.50±3.30)mm Hg of the observation group were better than(97.90±8.80)mm Hg,(42.30±3.50)%,(100.50±9.50)times/min,(18.90±2.20)times/min,(42.50±6.60)mm Hg of the control group,and the differences were all statistically significant(P<0.05).Conclusion Non-invasive ventilator combined with morphine can effectively improve patients'clinical symptoms and enhance the therapeutic effect with high safety.

关 键 词：急性左心衰 无创呼吸机 吗啡 治疗效果 不良反应 

分 类 号：R541.6[医药卫生—心血管疾病]