鸦胆子的化学成分、药理作用研究进展及其质量标志物的预测分析  

Research progress in chemical constituents,pharmacological activity,and quality markers of Bruceae Fructus

作　　者：徐水宇 庄怡雪 詹志来 杨成梓[1,3] XU Shui-yu;ZHUANG Yi-xue;ZHAN Zhilai;YANG Cheng-zi(College of Pharmacy,Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China;National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China;Fujian Quality Monitoring and Technology Service Center for Chinese Materia Medica Raw Material,Fuzhou 350122,China)

机构地区：[1]福建中医药大学药学院,福建福州350122 [2]中国中医科学院中药资源中心,北京100700 [3]福建省级中药原料质量监测技术服务中心,福建福州350122

出　　处：《中国中药杂志》2022年第19期5158-5170,共13页China Journal of Chinese Materia Medica

基　　金：中医药公共卫生服务补助专项“全国中药资源普查项目”[财社(2017)66号,财社(2019)39号];中央本级重大增减支项目(2060302)。

摘　　要：鸦胆子是我国传统中药材,其化学成分主要包括鸦胆子油、苦木内酯类、黄酮类、甾体类、三萜类、生物碱类等。现代研究表明鸦胆子具有抗肿瘤、抗疟疾、抗炎、降脂等多种药理活性。笔者在对鸦胆子的资源分布、化学成分、药理作用综述的基础上,以质量标志物(Q-marker)为核心概念,从化学成分的特有性、传统药效、化学成分可测性、不同配伍以及临床疗效等多个方面对鸦胆子的质量标志物进行预测,推测鸦胆子中油酸、亚油酸、鸦胆子苦醇、鸦胆丁、鸦胆子素A、鸦胆子素B、鸦胆子素C、鸦胆子素D可作为鸦胆子的质量标志物,以期为鸦胆子质量标准的建立提供参考依据。Bruceae Fructus is a Chinese herbal medicine with the chemical constituents mainly including Brucea javanica oil,quassinoids,flavonoids,steroids,triterpenoids,and alkaloids.Modern research demonstrates that Bruceae Fructus has anti-tumor,anti-malaria,anti-inflammatory,and lipid-lowering activities.This paper introduces the resource distribution,chemical constituents,and pharmacological activities of Bruceae Fructus.Further,according to the concept of quality marker(Q-marker),this paper predicts the Q-markers of Bruceae Fructus from the specificity of chemical components,pharmaceutical activity,measurability of chemical constituents,compatibility,and clinical efficacy,aiming to provide a theoretical basis for establishing the quality standard of Bruceae Fructus.

关 键 词：鸦胆子 资源分布 化学成分 药理活性 质量标志物 

分 类 号：R284.1[医药卫生—中药学] R285[医药卫生—中医学]