汉族、藏族高海拔世居心房颤动患者SCN5A基因H558R位点多态性分析  

Analysis of SCN5A Gene H558R Polymorphism in Patients with Atrial Fibrillation in Han and Tibetan Nationality at High Altitude

作　　者：许萍 马晓峰 曹建东 王红 XU Ping;MA Xiao-feng;CAO Jian-dong;WANG Hong(Department of Cadre Health,Cardiovascular and Cerebrovascular Disease Hospital of Qinghai Province,Xining 810001,China)

机构地区：[1]青海省心脑血管病专科医院干部保健科,西宁810001

出　　处：《临床误诊误治》2022年第10期48-52,共5页Clinical Misdiagnosis & Mistherapy

基　　金：青海省卫生和计划生育委员会科研课题(2018-wjzdx-34)。

摘　　要：目的分析汉族、藏族高海拔世居心房颤动(AF)患者电压依赖性钠离子通道α1亚基(SCN5A)基因H558R位点多态性。方法选取2019年1月-2022年5月收治的260例AF作为AF组(汉族130例,藏族130例),以同期200例无AF者为对照组(汉族100例,藏族100例),比较2组汉族、藏族中一般资料、H558R位点基因型及等位基因频率分布情况。结果多因素Logistic回归分析显示,年龄、左心房前后径(LAD)是汉族高海拔世居人群AF发生的独立危险因素,年龄、LAD、携带等位基因G是藏族高海拔世居人群AF发生的独立危险因素(P<0.05,P<0.01)。结论汉族、藏族高海拔世居AF患者SCN5A基因H558R位点多态性存在民族差异,携带等位基因G的藏族高海拔世居人群更易发生AF。Objective To analyze the H558R polymorphism of SCN5A gene encoding the voltage dependent sodium ion channelsα1 in atrial fibrillation(AF)patients of Han and Tibetan nationalities at high altitude.Methods A total of 260 patients with AF admitted from January 2019 to May 2022 were selected as AF group(130 of Han nationality and 130 of Tibetan nationality),and 200 patients without AF in the same period were selected as control group(100 of Han nationality and 100 of Tibetan nationality).The general data,H558R genotype and allele frequency distribution of individuals of Han and Tibetan nationalities were compared between the two groups.Results Multivariate logistic regression analysis showed that age and left anterior posterior diameter(LAD)were independent risk factors for AF in high-altitude residents of Han nationality,while age,LAD and carrying allele G were independent risk factors for AF in high-altitude residents of Tibetan nationality(P<0.05,P<0.01).Conclusion The H558R polymorphism of SCN5A gene in high-altitude residents of Han and Tibetan nationalities with AF is different from each other,and high-altitude residents of Tibetan nationality with G allele are more likely to develop AF.

关 键 词：心房颤动 高海拔 居民 电压依赖性钠通道 H558R位点 基因多态性 

分 类 号：R541.75[医药卫生—心血管疾病]