柴胡桂枝干姜汤加味治疗不寐(肝郁痰凝证)的临床效果  

Modified Chaihu Guizhi Ganjiang decoction for insomnia (stagnation of liver-qi and phlegm)

作　　者：陈邦士[1] 吴爱玲[1] 石协桐 Chen Bangshi;Wu Ailing;Shi Xietong(Department of Traditional Chinese Medicine,Jieyang People's Hospital,Jieyang 522000,China)

机构地区：[1]揭阳市人民医院中医科,522000

出　　处：《国际医药卫生导报》2022年第23期3399-3402,共4页International Medicine and Health Guidance News

摘　　要：目的探讨柴胡桂枝干姜汤加味治疗不寐(肝郁痰凝证)的效果和安全性。方法选取2021年8月至2022年6月在揭阳市人民医院中医科门诊诊断为不寐(肝郁痰凝证)的患者60例,采用随机数字表法将患者分为观察组和对照组,各30例。观察组男10例,女20例,年龄(50.40±16.30)岁。对照组男8例,女22例,年龄(50.17±14.80)岁。观察组采用中药汤剂柴胡桂枝干姜汤加味治疗,对照组给予催眠药酒石酸唑吡坦片治疗,疗程2周。比较两组治疗前后阿森斯失眠量表(AIS)、中医证候评分和疗效及安全性。采用t检验和χ^(2)检验。结果对照组治疗前AIS评分(11.77±1.83)分,治疗后(6.63±1.30)分;观察组治疗前AIS评分(10.90±1.88)分,治疗后(4.80±1.50)分;两组治疗后AIS评分分别与治疗前比较,均明显减少,差异均有统计学意义(均P<0.05);治疗后,观察组AIS评分优于对照组,差异有统计学意义(P<0.05)。对照组治疗前中医证候积分为(9.50±1.61)分,治疗后(9.27±2.32)分;观察组治疗前中医证候积分(9.60±1.81)分,治疗后(4.17±1.86)分;观察组治疗后中医证候积分与治疗前对比,分值明显降低,差异有统计学意义(P<0.05)。对照组的有效率为73.33%(22/30),观察组的有效率为93.33%(28/30),两组疗效比较,观察组优于对照组,差异有统计学意义(P<0.05)。对照组不良反应发生率为33.33%(10/30),观察组为10.00%(3/30),差异有统计学意义(P<0.05)。结论柴胡桂枝干姜汤加味治疗不寐(肝郁痰凝证)疗效确切,能改善患者的睡眠质量,减轻患者伴随的不适症状,不良反应少。Objective To evaluate the effectiveness and safety of modified Chaihu Guizhi Ganjiang decoction for insomnia(stagnation of liver-qi and phlegm).Methods Sixty cases of insomnia patients diagnosed as stagnation of liver-qi and phlegm treated at Department of Traditional Chinese Medicine,Jieyang People's Hospital from August 2021 to June 2022 were selected,and were divided into an observation group and a control group by the random number table method,with 30 cases in each group.There were 10 males and 20 females in the observation group,and they were(50.40±16.30)year old.There were 8 males and 22 females in the control group,and they were(50.17±14.80)year old.The observation group were treated with modified Chaihu Guizhi Ganjiang decoction,and the control group with hypnotics(zolpidem tartrate),for 2 weeks.The scores of Athens Insomnia Scale(AIS)and traditional Chinese medicine(TCM)syndromes,effectiveness,and safety in the two groups were observed and compared.t andχ^(2)tests were applied.Results The AIS scores before and after the treatment were(11.77±1.83)and(6.63±1.30)in the control group,and were(10.90±1.88)and(4.80±1.50)in the observation group;the AIS scores of the two groups after the treatment were significantly lower than those before the treatment,with statistical differences(both P<0.05);the AIS score of the observation group after the treatment was much better than that of the control group,with a statistical difference(P<0.05).The TCM syndrome scores before and after the treatment were(9.50±1.61)and(9.27±2.32)in the control group,and were(9.60±1.81)and(4.17±1.86)in observation group;the TCM syndrome score of the observation group after the treatment was significantly lower than that before the treatment,with a statistical difference(P<0.05).The effective rate was 73.33%(22/30)in the control group,and was 93.33%(28/30)in the observation group,with a statistical difference(P<0.05).The incidence of adverse reactions was 33.33%(10/30)in the control group,and was 10.00%(3/30)in the observation gr

关 键 词：不寐 柴胡桂枝干姜汤加味 肝郁痰凝 

分 类 号：R256.23[医药卫生—中医内科学]