亚洲带绦虫病患者血清IL-4和IL-10含量检测  

Detection of serum IL-4 and IL-10 in patients with Taeniasis asiatica

作　　者：蔡倩文 赵俊杰 李海龙 董玲 张莉 CAI Qianwen;ZHAO Junjie;LI Hailong;DONG Ling;ZHANG Li(Department of Parasitology,School of Basic Medical Sciences,Dali University,Dali 671000,China;Yunnan Key Laboratory of Screening and Research on Anti-pathogenic Plant Resources from Western Yunnan Dali)

机构地区：[1]大理大学基础医学院寄生虫教研室,云南大理671000 [2]云南省滇西抗病原植物资源筛选研究重点实验室

出　　处：《河南预防医学杂志》2022年第10期804-806,共3页Henan Journal of Preventive Medicine

基　　金：云南省科技厅地方联合专项项目2019FH001(-014);大理大学媒介生物学创新团队基金(ZKLX2019104)。

摘　　要：目的 检测亚洲带绦虫病患者血清IL-4和IL-10含量,探讨亚洲带绦虫病患者Th2型免疫反应特点。方法 选取健康体检者和亚洲带绦虫病患者各69例,分别为A、B组;9例对应的驱虫前后患者分别为C、D组。采用ELISA方法检测各组研究对象血清IL-4和IL-10含量,并对结果进行统计分析。结果 B组血清IL-4和IL-10含量分别为10.62(9.24,11.60)、7.29(6.12,10.54)pg/mL,均低于A组11.81(10.58,13.54)、8.23(6.70,11.77)pg/mL,差异有统计学意义(Z=-3.84,P<0.001;Z=-2.94,P<0.01)。C、D两组血清IL-4和IL-10含量差异无统计学意义(Z=-1.24,P>0.05;Z=-1.72,P>0.05)。结论 感染亚洲带绦虫患者血清IL-4和IL-10含量下降,其通过抑制人体Th2型免疫,发挥免疫逃避作用。Objective To detect the contents of serum IL-4 and IL-10,and explore the characteristics of Th2 immune response in patients with Taenia asiatica taeniasis.Methods In total,69 healthy people and 69 patients with T.asiatica taeniasis were assigned into group A and group B,respectively,and of them,9 patients with T.asiatica who had one-month anthelmintic treatment were referred to group C in pre-treatment and group D in post-treatment.The contents of serum IL-4 and IL-10 were detected by ELISA,and the data were analyzed with statistical method.Results The serum levels of IL-4 and IL-10 in group B were 10.62(9.24,11.60) and 7.29(6.12,10.54) pg/mL,respectively,which were both lower than those in group A,11.81(10.58,13.54) and 8.23(6.70,11.77) pg/mL,and the differences were statistically significant(Z=-3.84,P<0.001;Z=-2.94,P<0.01).There were no significant differences in serum IL-4 and IL-10 levels between groups C and D(Z=-1.24,P>0.05;Z=-1.72,P>0.05).Conclusion The contents of serum IL-4 and IL-10 decreased in patients infected with Taenia asiatica,which play an immune evasion role by inhibiting human Th2 immunity.

关 键 词：亚洲带绦虫 Th2型免疫 IL-4 IL-10 

分 类 号：X82[环境科学与工程—环境工程]