血浆Mg^(2+)浓度与血脂、血尿酸的关系及其初步机制分析  

Correlation and potential mechanism of plasma magnesium concentration with blood lipids and uric acid

作　　者：韩拓 姚智会 范雅洁 巩红 郑阳[1] 王丽霞[1] 王怡雯 王聪霞[1] Han Tuo;Yao Zhi-Hui;Fan Ya-Jie;Gong Hong;Zheng Yang;Wang Li-Xia;Wang Yi-Wen;Wang Cong-Xia(Department of Cardiology,the Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an,Shaanxi 710004,China;Department of Health Management,the Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an,Shaanxi 710004,China)

机构地区：[1]西安交通大学第二附属医院心血管内科,陕西西安710004 [2]西安交通大学第二附属医院健康管理部,陕西西安710004

出　　处：《解放军医学杂志》2022年第11期1116-1124,共9页Medical Journal of Chinese People's Liberation Army

基　　金：国家自然科学基金(81273878);陕西省自然科学基金青年基金(2021JQ-409)。

摘　　要：目的探讨血浆Mg^(2+)浓度与血脂、血尿酸代谢之间的关系及其潜在机制。方法收集西安交通大学第二附属医院2018年9月-2021年5月的健康人群体检数据,根据血浆Mg^(2+)浓度分为低Mg^(2+)组(≤1.65 mmol/L)与高Mg^(2+)组(>1.65 mmol/L),比较两组间血脂与血尿酸的差异;采用Spearman检验分析Mg^(2+)浓度与血脂、血尿酸代谢之间的相关性;按性别与年龄分亚组进行比较;基于毒性与基因比较数据库(CTD)及OMIM等疾病相关数据库,挖掘与Mg^(2+)及血脂异常相关的基因并进行匹配,构建蛋白互作(PPI)网络,并进行GO与KEGG富集分析。结果与低Mg^(2+)组比较,高Mg^(2+)组血尿酸[(288.88±80.44)mg/dl vs.(325.00±83.38)mg/dl,P<0.001]、总胆固醇[TC,(4.27±0.85)mmol/L vs.(4.52±0.87)mmol/L,P<0.001]、三酰甘油[TG,(1.31±0.97)mmol/L vs.(1.70±1.33)mmol/L,P<0.001]及低密度脂蛋白胆固醇[LDL-C,(2.62±0.76)mmol/L vs.(2.85±0.75)mmol/L,P<0.001]水平均明显升高,高密度脂蛋白胆固醇水平[HDL-C,(1.33±0.34)vs.(1.25±0.30)mmol/L,P<0.001]明显降低。Spearman相关分析显示,血浆Mg^(2+)与血尿酸、TC、TG、LDL-C呈明显正相关(r分别为0.237、0.154、0.254、0.170,P<0.001),而与HDL-C呈明显负相关(r=–0.154,P<0.001)。男性与女性亚组分析与上述结果基本一致,且差异主要集中于20~40岁及40~60岁年龄段人群。基因挖掘结果显示,Mg^(2+)与血脂异常之间存在12个共同基因;GO和KEGG富集分析结果显示,Mg^(2+)可能作用于胰岛素、SREBF1、HMGCR、LCAT、CD36等肝脏脂质合成与代谢靶点,影响腺苷酸蛋白活化激酶(AMPK)通路及胰岛素抵抗、动脉粥样硬化等的发生与进展。结论健康人群中血浆Mg^(2+)升高与血脂异常和高尿酸血症具有一定相关性,Mg^(2+)可能调控肝脏脂质代谢与胰岛素通路,参与血脂异常、胰岛素抵抗及动脉粥样硬化的发生。Objective To explore the correlation and potential mechanism of plasma magnesium(Mg^(2+))concentration with blood lipids and uric acid.Methods The physical examination data of healthy population from September 2018 to May 2021 were collected from the Second Affiliated Hospital of Xi'an Jiaotong University,and divided into two groups according to the plasma Mg^(2+)concentration(low Mg^(2+)group,≤1.65 mmol/L;high Mg^(2+)group,>1.65 mmol/L).The differences of blood lipids and uric acid were compared between the two groups.Spearman correlation analysis was performed to analyze the correlation of plasma Mg^(2+)concentration and the metabolism of blood lipids and uric acid.Subgroups were set up according to gender and age,and based on the Comparative Toxicogenomics Database(CTD)and other disease-related databases,genes related to Mg^(2+)and dyslipidemia were extracted and matched,protein interaction(PPI)network was constructed,and gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis were performed.Results Uric acid[(288.88±80.44)mg/dl vs.(325.00±83.38)mg/dl,P<0.001],total cholesterol[TC,(4.27±0.85)mmol/L vs.(4.52±0.87)mmol/L,P<0.001],triglyceride[TG,(1.31±0.97)mmol/L vs.(1.70±1.33)mmol/L,P<0.001]and low-density lipoprotein cholesterol[LDL-C,(2.62±0.76)mmol/L vs.(2.85±0.75)mmol/L,P<0.001]were significantly increased in healthy population with higher Mg^(2+)concentration,while high-density lipoprotein cholesterol(HDL-C)decreased significantly[(1.33±0.34)mmol/L vs.(1.25±0.30)mmol/L,P<0.001].Spearman correlation analysis showed that plasma Mg^(2+)was positively correlated with uric acid(r=0.237,P<0.001),TC(r=0.154,P<0.001),TG(r=0.254,P<0.001),LDL-C(r=0.170,P<0.001),while negatively correlated with HDL-C(r=–0.154,P<0.001).Analyzed results in male and female subgroups were basically consistent with the above results,and the differences mainly come from the age group of 20-40 years old and 40-60 years old.In addition,there were 12 matched genes between Mg^(2+)and dyslipidemia.GO

关 键 词：镁 血脂异常 尿酸 胰岛素抵抗 动脉粥样硬化 

分 类 号：R589.2[医药卫生—内分泌]