Cys C、PAI-1与急性心肌梗死的早期诊断及疾病严重程度的相关性分析  

Correlation of Cys C,PAI-1 and early diagnosis and severity of acute myocardial infarction

作　　者：李帅[1] 金爱莲[1] 刘青[1] 苏健康[1] 贺醒 李胜利[1] 严鸣光[2] LI Shuai;JIN Ailian;LIU Qing;SU Jiankang;HE Xing;LI Shengli;YAN Mingguang(Cardiac Intensive Care Unit,Shangqiu First People's Hospital of Henan Province,Shangqiu,Henan,China,476000;Department of Clinical Laboratory,Shangqiu First People's Hospital of Henan Province,Shangqiu,Henan,China,476000)

机构地区：[1]河南省商丘市第一人民医院心脏重症监护室,河南商丘476000 [2]河南省商丘市第一人民医院检验科,河南商丘476000

出　　处：《分子诊断与治疗杂志》2022年第11期1968-1971,共4页Journal of Molecular Diagnostics and Therapy

基　　金：河南省医学科技公关计划项目(LHGJ20200931)。

摘　　要：目的 探讨血清胱抑素C(Cys C)、纤溶酶原激活物抑制剂-1(PAI-1)在急性心肌梗死早期诊断中的价值及其与疾病严重程度的相关性。方法 选取2020年8月至2021年12月商丘市第一人民医院心内科收治的152例急性心肌梗死(AMI)作为观察组,并选取同期健康体检者152名作为对照组。按照疾病危险程度评价标准将观察组患者分为低危组(n=82)、中危组(n=48)以及高危组(n=22)。比较观察组和对照组患者的Cys C、PAI-1水平。比较低危组、中危组以及高危组的Cys C、PAI-1水平。采用Spearman分析分析Cys C、PAI-1与AMI疾病严重程度的相关性。采用多因素Logistic回归分析AMI的独立危险因素,并采用受试者工作(ROC)曲线分析Cys C、PAI-1在AMI早期诊断中的价值。结果 观察组的Cys C、PAI-1水平显著高于对照组,差异有统计学意义(t=9.649,22.649,P<0.05);Cys C、PAI-1在不同疾病严重程度的患者中的水平:低危组<中危组<高危组(F=26.227,81.652,P<0.05),具有吸烟史、高血压的患者比例:低危组<中危组<高危组,差异均有统计学意义(P<0.05);Cys C、PAI-1水平均与AMI疾病严重程度呈正相关(r=0.527、0.601,P<0.05);Cys C、PAI-1为AMI的独立危险因素(P<0.05),且Cys C、PAI-1以及两者联合检测的AUC为0.721、0.782、0.912。结论 Cys C、PAI-1水平与AMI的疾病严重程度具有一定的相关性,并且Cys C、PAI-1在AMI的早期诊断中具有诊断价值,且两者联合检测的诊断价值高于单独检测的诊断价值,两者联合检测可以作为AMI早期诊断的新途径。Objective To investigate the value of Cys C and PAI-1 in the early diagnosis of acute myocardial infarction and their correlation with the severity of the disease. Methods From August 2020 to December 2021,152 cases of acute myocardial infarction(AMI)admitted to the Department of Cardiology,Shangqiu First People’s Hospital were selected as the observation group,and 152 healthy subjects during the same period were selected as the control group. According to the evaluation criteria of disease risk,the patients in the observation group were divided into the low-risk group(n=82),the intermediate-risk group(n=48)and the high-risk group(n=22). The levels of Cys C and PAI-1 in the observation group and the control group were compared. The levels of Cys C and PAI-1 in the low-risk group,intermediate-risk group and high-risk group were compared. Spearman analysis was used to analyze the correlation between Cys C,PAI-1 and the severity of AMI. Multivariate Logistic regression was used to analyze the independent risk factors of AMI,and the receiver operating(ROC)curve was used to analyze the value of Cys C and PAI-1 in the early diagnosis of AMI. Results The levels of Cys C and PAI-1 in the observation group were significantly higher than those in the control group(t=9.649,22.649,P<0.05). The proportion of patients with smoking history and hypertension:low-risk group < intermediate-risk group < high-risk group(F=26.227,81.652,P<0.05). Cys C and PAI-1 levels were positively correlated with the severity of AMI(r=0.527,0.601,P<0.05). Cys C and PAI-1were independent risk factors for AMI(P<0.05),and the AUCs of Cys C,PAI-1 and their combined detection were 0.721,0.782,and 0.912. Conclusion The levels of Cys C and PAI-1 have a certain correlation with the disease severity of AMI,and Cys C and PAI-1 have diagnostic value in the early diagnosis of AMI,and the diagnostic value of combined detection is higher than that of single detection.

关 键 词：Cys C PAI-1 急性心肌梗死 早期诊断 疾病严重程度 

分 类 号：R542.22[医药卫生—心血管疾病]