有限内固定结合微型外固定架对骨折患者OPG、CRP及RANK的影响  

Effects of limited internal fixation combined with miniature external fixator on OPG,CRP and RANK in patients with fractures

作　　者：梁丽霞 吴锦 张莉 LIANG Lixia;WU Jin;ZHANG Li(Department of Operating Room,Shangqiu Municipal Hospital,Shangqiu,Henan,China,476100;Department of Orthopedics,Shangqiu Municipal Hospital,Shangqiu,Henan,China,476100)

机构地区：[1]商丘市立医院手术室,河南商丘476100 [2]商丘市立医院骨科,河南商丘476100

出　　处：《分子诊断与治疗杂志》2022年第11期1981-1984,共4页Journal of Molecular Diagnostics and Therapy

基　　金：河南省科技发展计划基金资助项目(182102311245)。

摘　　要：目的 研究有限内固定结合微型外固定架对骨折患者护骨素(OPG)、C反应蛋白(CRP)、细胞核因子kB受体活化因子(RANK)的影响。方法 选取2018年10月至2021年5月商丘市立医院收治的98例骨折患者,根据治疗方式不同分为内固定组(内固定治疗,n=47)和内外固定组(有限内固定结合微型外固定架治疗,n=51),比较两组关节功能、围术期情况、治疗前后OPG、CRP、RANK水平及并发症情况。结果 内外固定组总效率(94.12%)高于内固定组(78.72%),差异有统计学意义(P<0.05)。内外固定组术中出血量少于内固定组,手术时间、术后负重时间、骨折愈合时间、住院时间短于内固定组,差异有统计学意义(P<0.05)。治疗后内外固定组RANK、CRP低于内固定组,OPG高于内固定组,差异有统计学意义(P<0.05)。内外固定组并发症率(5.88%)低于内固定组(19.15%),差异有统计学意义(P<0.05)。结论 有限内固定结合微型外固定架治疗骨折的效果显著,可促进患者关节功能术后恢复,具有较高安全性。Objective To study the effects of limited internal fixation combined with miniature external fixator on osteoprotegerin(OPG),C-reaction protein(CRP),and receptor activator of NF-kB Ligand(RANK)in fracture patients. Methods 98 fracture patients admitted to Shangqiu Municipal Hospital from October 2018 to May 2021 were selected,according to different treatment methods,they are divided into the internal fixation group(internal fixation treatment,n=51)and the internal and external fixation group(limited internal fixation combined with micro-external fixator treatment,n=47). The joint functions(using Harris hip function score method to determine),perioperative conditions,OPG,CRP,RANK levels before and after treatment,and complications between the two groups are compared. Results The total effective rate of the internal and external fixation group(94.12%)was higher than that of the internal fixation group(78.72%),and the difference was statistically significant(P<0.05). The intraoperative blood loss in the internal and external fixation group was less than that in the internal fixation group,and the operation time,postoperative weightbearing time and hospital stay in the study group were shorter than those in the internal fixation,and the difference was statistically significant(P<0.05). After treatment,the RANK,CRP in the internal and external fixation group was lower than thode in the internal fixation group,and the OPG was higher than that in the internal fixation group,and the difference was statistically significant(P<0.05). The complication rate of the internal and external fixation group(5.88%)was significantly lower than that of the internal fixation group(19.15%),and the difference was statistically significant(P<0.05). Conclusion The limited internal fixation combined with the miniature external fixator has a significant effect in the treatment of fractures,and can promote the postoperative recovery of the patients’ joint function with high safety.

关 键 词：骨折 有限内固定 微型外固定 OPG CRP RANK 

分 类 号：R687.3[医药卫生—骨科学]