木犀草素治疗阿尔茨海默病的作用机制研究进展  

Recent progress of neuroprotective mechanisms of luteolin in Alzheimer’s disease

作　　者：孙会艳[1,2] 周立燕 任丽雪 李强 王洪权 SUN Hui-yan;ZHOU Li-yan;REN Li-xue;LI Qiang;WANG Hong-quan(Chifeng University Health Science Center,Chifeng,Inner Mongolia 024000,China;Key Laboratory of Human Genetic Diseases in Inner Mongolia,Chifeng,Inner Mongolia 024000,China;Dept of Neurology,Inner Mongolia Minzu University,Tongliao,Inner Mongolia 028000,China;Dept of Neurology,the Affiliated Hospital of Chifeng University,Chifeng,Inner Mongolia 024005,China;Dept of Neurology,Aerospace Center Hospital,Peking University Aerospace School of Clinical Medicine,Beijing 100049,China)

机构地区：[1]赤峰学院医学部,内蒙古赤峰024000 [2]内蒙古人类遗传病研究重点实验室,内蒙古赤峰024000 [3]内蒙古民族大学神经内科,内蒙古通辽028000 [4]赤峰学院附属医院神经内科,内蒙古赤峰024005 [5]航天中心医院、北京大学航天临床医学院神经内科,北京100049

出　　处：《中国药理学通报》2022年第12期1781-1785,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金项目(No 81260196,81450036);内蒙古自治区高等学校青年科技英才支持计划(No NJYT-17-B23);内蒙古自治区高校科研项目(No NJZY19218);内蒙古自然科学基金项(No 2020MS08175,2021MS08131,2021LHMS08024);内蒙古草原英才计划项目(No CYYC7055);航天医科科研基金资助项目(No 2020YK02,2021YK05)。

摘　　要：木犀草素(luteolin)是一种重要的黄酮类化合物,存在于多种天然植物中,具有多种药理活性。近年来,在实验性阿尔茨海默病(Alzheimer’s disease,AD)模型中,木犀草素具有神经保护作用而成为研究最广泛的植物化学药物之一。其可抑制胆碱酯酶活性、调控β-淀粉样蛋白(β-amyloid,Aβ)生成和聚集、调控tau蛋白磷酸化、调控脑内葡萄糖代谢、抗神经炎症、抗氧化和抗凋亡作用等,而在AD中发挥神经保护作用。该文对木犀草素在AD中的运用基础研究及其可能的神经保护作用及其机制进展进行总结和归纳,以期对后续研究起指导作用。Luteolin is a widely distributed type of flavone herbs and vegetables,which has diverse pharmacological activities against human ailments including Alzheimer’s disease(AD).Recently,luteolin has been the most widely studied phytochemicals for their neuroprotective effects against experimental models of AD.Luteolin also improves brain insulin sensitivity and neuroinflammation,which attenuates the phosphorylation of tau and the formation of tangles,and the tendency of Aβto form deposits.Furthermore,luteolin has anti-oxidative stress and anti-apoptosis effect in AD.The present study aims at reviewing experimental studies and describing the possible underlying molecular mechanisms by which luteolin and the related compounds protect against AD.

关 键 词：木犀草素 阿尔茨海默病 神经保护 Β-淀粉样蛋白 氧化应激 神经炎症 

分 类 号：R284.1[医药卫生—中药学] R341[医药卫生—中医学] R349.1R364.5R745.705