盐酸左西替利嗪口服溶液联合孟鲁司特钠咀嚼片治疗儿童慢性荨麻疹的效果观察  

Effectiveness of Levocetirizine Hydrochloride Oral Solution Combined with Montelukast Sodium Chewable Tablets in the Treatment of Chronic Urticaria in Children

作　　者：张继玲[1] 谭张龙 金广连 Zhang Ji-ling;Tan Zhang-long;Jin Guang-lian(Pizhou People's Hospital,Pizhou 221300,Jiangsu Province,China)

机构地区：[1]江苏省邳州市人民医院,江苏邳州221300

出　　处：《中国社区医师》2022年第32期74-76,共3页Chinese Community Doctors

摘　　要：目的:探讨盐酸左西替利嗪口服溶液联合孟鲁司特咀嚼片治疗儿童慢性荨麻疹的效果。方法:选取2020年6月-2021年2月江苏省邳州市人民医院收治的44例慢性荨麻疹患儿作为研究对象,按随机法分为对照组和试验组,各22例。对照组应用盐酸左西替利嗪口服溶液治疗,试验组在对照组基础上应用孟鲁司特钠咀嚼片治疗。比较两组治疗前后临床症状积分、血清因子水平、复发率及不良反应发生率。结果:治疗前,两组皮肤瘙痒程度、风团大小、风团数量各项临床症状积分及总分比较,差异无统计学意义(P>0.05);治疗后,两组皮肤瘙痒程度、风团大小、风团数量各项临床症状积分及总分均低于治疗前,且试验组均低于对照组,差异有统计学意义(P<0.05)。治疗前,两组血清总免疫球蛋白E(IgE)、白介素-4(IL-4)、白细胞介素-18(IL-18)水平比较,差异无统计学意义(P>0.05)。治疗后,两组IgE、IL-4水平均低于治疗前,IL-18水平均高于治疗前,差异有统计学意义(P<0.05);试验组IgE、IL-4水平均低于对照组,IL-18水平高于对照组,差异有统计学意义(P<0.05)。治疗期间,两组不良反应发生率比较,差异无统计学意义(P>0.05);停药3个月后,试验组复发率低于对照组,差异有统计学意义(P<0.05)。结论:盐酸左西替利嗪口服溶液联合孟鲁斯特钠咀嚼片治疗儿童慢性荨麻疹的效果显著,可有效缓解机体变态反应,改善荨麻疹症状,安全性高且复发率低,值得推广。Objective:To investigate the effectiveness of levocetirizine hydrochloride oral solution combined with montelukast sodium chewable tablets in the treatment of chronic urticaria in children.Methods:Forty-four cases of children with chronic urticaria admitted to Pizhou People's Hospital in Jiangsu Province from June 2020 to February 2021 were selected as study subjects and divided into control group and experimental group by random method,22 cases each.The control group was treated with levocetirizine hydrochloride oral solution,and the test group was treated with montelukast sodium chewable tablets on the basis of the control group.The clinical symptom score,serum factor level,recurrence rate and incidence of adverse reactions were compared between the two groups before and after treatment.Results:Before treatment,there were no statistically significant differences in the clinical symptom scores and total scores of each clinical symptom comparing the degree of skin pruritus,the size of wind masses and the number of wind masses between the two groups(P>0.05).After treatment,the clinical symptom scores and total scores of the degree of skin itching,the size of wind masses and the number of wind masses in both groups were lower than those before treatment,and the test group was lower than the control group,and the difference was statistically significant(P<0.05).Before treatment,the serum total immunoglobulin E(IgE),interleukin-4(IL-4)and interleukin-18(IL-18)levels of the two groups were compared,and the differences were not statistically significant(P>0.05).After treatment,IgE and IL-4 levels were lower and IL-18 levels were higher in both groups than before treatment,and the differences were statistically significant(P<0.05).In the test group,IgE and IL-4 levels were lower than those in the control group,and IL-18 levels were higher than those in the control group,with statistically significant differences(P<0.05).During the treatment period,there was no statistically significant difference in the incidence of adv

关 键 词：盐酸左西替利嗪口服溶液 孟鲁司特钠 慢性荨麻疹 儿童 复发率 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]