心房颤动老年患者血清半乳糖凝集素3的表达及对其预后的影响  

Expression of serum galectin-3 in elderly patients with atrial fibrillation and its impact on prognosis

作　　者：彭洁婷 谭胜玉[1] 董莉妮[1] 张湘瑜[1] Peng Jieting;Tan Shengyu;Dong Lini;Zhang Xiangyu(Department of Geriatrics,Second Xiangya Hospital,Central South University,Changsha 410011)

机构地区：[1]中南大学湘雅二医院老年医学科,长沙410011

出　　处：《中华老年医学杂志》2022年第11期1284-1289,共6页Chinese Journal of Geriatrics

基　　金：长沙市科技局(kq2001040)。

摘　　要：目的观察心房颤动(房颤)老年患者与非房颤患者血清半乳糖凝集素3的表达水平差异,并探讨其对房颤患者预后的影响。方法回顾性研究,连续入选2018年3—9月中南大学湘雅二医院老年心血管内科年龄≥60岁患者100例,根据心电图及既往房颤病史分为房颤组73例,非房颤组27例。采用酶联免疫吸附试剂盒检测两组患者半乳糖凝集素3的表达水平,超声心动图测量患者各房室大小指标。采用曼-惠特尼检验比较两组间半乳糖凝集素3水平,二元Logistic回归分析确定老年房颤的危险因素。采用Kaplan-Meier生存曲线、Cox比例风险回归分析生存率及半乳糖凝集素3与预后的关系。结果血清半乳糖凝集素3水平房颤组患者高于非房颤组[(395.13±113.24)ng/L比(328.53±89.11)ng/L,t=2.626,P<0.01]。年龄≥65岁组(48例)患者半乳糖凝集素3水平高于<65岁组(52例),(414.01±105.03)ng/L比(343.11±106.01)ng/L(t=2.626,P<0.01)。血清半乳糖凝集素3水平与年龄(r=0.40,P<0.01)、房颤持续时间(r=0.224,P<0.05)及C反应蛋白(r=0.305,P<0.01)呈正相关,与N-末端脑钠肽前体及心脏各房室大小、CHA2DS2-VASc评分无相关性。血清半乳糖凝集素3是影响房颤发生的危险因素(P<0.05)。半乳糖凝集素3水平不影响房颤患者生存率(Log-rank=0.990)和预后(P>0.05)。结论房颤老年患者半乳糖凝集素3的表达水平高于非房颤患者,半乳糖凝集素3水平与年龄、房颤时间、C反应蛋白相关。血清半乳糖凝集素3是老年人发生房颤患者的危险因素。Objective To investigate the expression of serum galectin-3 in elderly patients with or without atrial fibrillation and to explore its impact on the prognosis of patients with atrial fibrillation.Methods In this retrospective study,100 patients aged 60 years or older treated at the Department of Geriatric Cardiovascular Medicine,Second Xiangyang Hospital,Central South University between March 2018 and September 2018 were enrolled.Based on electrocardiogram and previous history of atrial fibrillation,73 participants were assigned to the atrial fibrillation group and 27 patients with sinus rhythm and no history of atrial fibrillation during the same period served as the control group.Elisa kits were used to measure the expression of galectin-3 in both groups,and echocardiography was used to measure the size of each cardiac chamber in patients.The Mann-Whitney test was used to compare galectin-3 levels between the two groups,and binary logistic regression analysis was used to determine risk factors for atrial fibrillation in the elderly.Kaplan-Meier survival curves and Cox proportional risk regression were used to analyze survival and the relationship between galectin-3 and prognosis.Results Serum galectin-3 levels of patients in the atrial fibrillation group were higher than in the control group[(395.13±113.24)ng/L vs.(328.53±89.11)ng/L,t=2.626,P<0.01].The level of galectin 3 in participants aged≥65 years(n=48)was higher than in those aged<65 years(n=52),(414.01±105.03)ng/L vs.(343.11±106.01)ng/L(t=2.626,P<0.01).The galectin-3 level had a positive correlation with age(r=0.40,P<0.01),duration of atrial fibrillation(r=0.224,P<0.05)and C-reactive protein(r=0.305,P<0.01),but no correlation with N-terminal pro-B-type natriuretic peptide,atrial or ventricular size and the score of CHA2DS2-VASc in patients with atrial fibrillation,.Galectin-3 was a risk factor in patients with atrial fibrillation(P<0.01).Galectin-3 levels did not affect survival(log-rank=0.990)or prognosis(P>0.05)in patients with atrial fibrillation

关 键 词：半乳糖凝集素3 心房颤动 C反应蛋白 

分 类 号：R541.75[医药卫生—心血管疾病]