Pattern transition and regulation in a subthalamopallidal network under electromagnetic effect  

作　　者：Zilu Cao Lin Du Honghui Zhang Yuzhi Zhao Zhuan Shen Zichen Deng 曹子露;都琳;张红慧;赵玉枝;申转;邓子辰(School of Mathematics and Statistics,Northwestern Polytechnical University,Xi'an 710129,China;School of Aeronautics,Northwestern Polytechnical University,Xi'an 710072,China;MIIT Key Laboratory of Dynamics and Control of Complex Systems,Xi'an 710129,China)

机构地区：[1]School of Mathematics and Statistics,Northwestern Polytechnical University,Xi'an 710129,China [2]School of Aeronautics,Northwestern Polytechnical University,Xi'an 710072,China [3]MIIT Key Laboratory of Dynamics and Control of Complex Systems,Xi'an 710129,China

出　　处：《Chinese Physics B》2022年第11期626-637,共12页中国物理B（英文版）

基　　金：Project supported by the National Natural Science Foundation of China(Grant Nos.11972292,12172291,and 12072265);the 111 Project(Grant No.BP0719007)。

摘　　要：Although the significant roles of magnetic induction and electromagnetic radiation in the neural system have been widely studied,their influence on Parkinson’s disease(PD)has yet to be well explored.By virtue of the magnetic flux variable,this paper studies the transition of firing patterns induced by magnetic induction and the regulation effect of external magnetic radiation on the firing activities of the subthalamopallidal network in basal ganglia.We find:(i)The network reproduces five typical waveforms corresponding to the severity of symptoms:weak cluster,episodic,continuous cluster,episodic,and continuous wave.(ii)Magnetic induction is a double-edged sword for the treatment of PD.Although the increase of magnetic coefficient may lead the physiological firing activity to transfer to pathological firing activity,it also can regulate the pathological intensity firing activity with excessiveβ-band power transferring to the physiological firing pattern with weakβ-band power.(iii)External magnetic radiation could inhibit continuous tremulous firing andβ-band power of subthalamic nucleus(STN),which means the severity of symptoms weakened.Especially,the bi-parameter plane of the regulation region shows that a short pulse period of magnetic radiation and a medium level of pulse percentage can well regulate pathological oscillation.This work helps to understand the firing activity of the subthalamopallidal network under electromagnetic effect.It may also provide insights into the mechanisms behind the electromagnetic therapy of PD-related firing activity.

关 键 词：subthalamopallidal network magnetic induction and radiation pattern transition regulation of pathological oscillation 

分 类 号：R338[医药卫生—人体生理学] O441[医药卫生—基础医学]