寄生虫虫源性成分对宿主的毒理与药理效应  

The toxicological and pharmacological effects of parasite-derived components on the host

作　　者：徐志鹏[1,2] 季旻珺 吴观陵[1,2] XU Zhi-peng;JI Min-jun;WU Guan-ling(Department of Pathogen Biology,Jiangsu Province Key Laboratory of Modern Pathogen Biology,Nanjing Medical University,Nanjing 211166,China)

机构地区：[1]南京医科大学病原生物学系,南京211166 [2]江苏省现代病原生物学重点实验室,南京211166

出　　处：《中国寄生虫学与寄生虫病杂志》2022年第5期561-571,共11页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：国家自然科学基金面上项目(81971965);江苏省自然科学优秀青年基金(BK20211586);江苏省“青蓝工程”(KY101R202127);江苏省卫生健康委科研项目(Z2021004)。

摘　　要：近年来,一个新的转化医学命题——寄生虫虫源性成分对宿主的毒理与药理效应受到业内的广泛关注。从寄生虫-宿主长期进化过程形成的共适应角度深入理解寄生虫虫源分子对宿主产生的毒理与药理效应,不仅能加深从致病角度理解寄生虫的致病机制,而且有利于从治病角度研发基于虫源性成分的转化应用,已经成为并将继续成为寄生虫学研究领域最热门的研究任务之一。本文回顾近年来几种重要的引起人兽共患病的寄生虫及其虫源性成分诱导及调节宿主免疫代谢相关疾病的毒理与药理效应,并就寄生虫学的研究发展方向提出建议。In recent years, a new translational medicine proposition, the toxicological and pharmacological effects of parasite-derived components on the host, has received extensive attention. Therefore, an in-depth understanding of parasite-derived molecules ’ toxicological and pharmacological effects from the perspective of infection immunology can deepen our understanding of the pathogenesis of parasitic diseases but also facilitate research and develop-ment based on the concept of translational medicine. The transformational application value of parasite-derived molecules has become and will continue to be one of the most fantastic research tasks in the field of parasite re-search. This review focuses on recent advances in the pharmacological effects of zoonotic parasites and their derived components in inducing and regulating host immunometabolism-related diseases, and explores their potential mechanisms.

关 键 词：寄生虫 虫源性成分 毒理效应 药理效应 TREG细胞 

分 类 号：R53[医药卫生—内科学]