基于微生物-肠-脑轴理论探讨艾灸对孤独症谱系障碍儿童的治疗前景  

The Therapeutic Prospect of Moxibustion for Children with Autism Spectrum Disorder Based on Microbial-Gut-Brain Axis Theory

作　　者：王敏 尹树月 宋健 王静 邹卓 刘芸[2] WANG Min;YIN Shu-yue;SONG Jian;WANG Jing;ZOU Zhuo;LIU Yun(Yunnan University of Chinese Medicine,Kunming,Yunnan 650500;Kunming Children's Hospital,Kunming,Yunnan 650034)

机构地区：[1]云南中医药大学,云南昆明650500 [2]昆明市儿童医院,云南昆明650034

出　　处：《按摩与康复医学》2023年第1期52-56,共5页Chinese Manipulation and Rehabilitation Medicine

摘　　要：孤独症谱系障碍(ASD)是一组持续终身的神经发育障碍性疾病,常合并胃肠道症状、睡眠障碍等,现代研究表明ASD普遍存在肠道微生物异常,微生物-肠-脑轴与ASD具有交互作用,肠道微生物已是ASD的研究热点。艾灸是传统中医疗法的重要组成部分,艾灸可通过微生物-肠-脑轴达到治疗疾病的目的。本文检索相关文献,从肠道微生物、炎症因子、NF-κB通路、HPA轴、神经通路等方面进行总结,探索艾灸对孤独症谱系障碍儿童的治疗前景。Autism spectrum disorder(ASD)is a group of lifelong neurodevelopmental disorders,often accompanied by gastrointestinal symptoms,sleep disorders,etc.Modern studies have shown that intestinal microbiome abnormalities are common in ASD,and microbiome-gut-brain axis interacts with ASD.Intestinal microbiome has become a research hotspot of ASD.Moxibustion is an important part of traditional Chinese medicine therapy,and moxibustion can treat diseases through microbial-gut-brain axis.In this paper,relevant literatures were searched and summarized from intestinal microorganisms,inflammatory factors,NF-κB pathway,HPA axis,neural pathway,etc.,to explore the therapeutic prospect of moxibustion for children with autism spectrum disorder.

关 键 词：孤独症 艾灸 肠道微生物 肠脑轴 机制 研究进展 

分 类 号：R246[医药卫生—针灸推拿学]