β-榄香烯抗肿瘤药理作用机制及药物递送系统研究进展  

Research progress on antitumor pharmacological mechanism and drug delivery system ofβ-elemene

作　　者：郭金苗 孙玉姣 付慧 GUO Jinmiao;SUN Yujiao;FU Hui(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学,天津301617

出　　处：《药物评价研究》2022年第10期2133-2137,共5页Drug Evaluation Research

基　　金：国家自然科学基金青年资助项目(82104568);天津中医药大学研究生科研创新项目(YJSKC-20212014)。

摘　　要：β-榄香烯作为肿瘤治疗的辅助药物,其注射液和口服乳剂已被广泛用于治疗包括肺癌、肝癌、脑癌、乳腺癌在内的多种肿瘤。就β-榄香烯诱导肿瘤细胞凋亡、抑制肿瘤细胞迁移和侵袭、抑制肿瘤血管生长、逆转多药耐药和提高放化疗敏感性几方面的分子机制及其新型递药系统的开发进行综述,为β-榄香烯的抗肿瘤临床应用提供参考。β-elemene is used as an adjuvant drug in tumor therapy,and its injections and oral emulsions have been used to treat a variety of tumors including lung cancer,liver cancer,brain cancer and breast cancer.This article reviews the molecular mechanism ofβ-elemene in inducing tumor cell apoptosis,inhibiting tumor cell migration and invasion,inhibiting tumor vascular growth,reversing multidrug resistance and improving chemoradiotherapy sensitivity,as well as the development of novel drug delivery systems,providing reference for the further development and clinical application ofβ-elemene as antitumor therapy.

关 键 词：Β-榄香烯 抗肿瘤 药理机制 药物递送系统 细胞凋亡 多药耐药 

分 类 号：R285.5[医药卫生—中药学] R979.1[医药卫生—中医学]