中医阴阳转化思维不对称性的认知神经加工机制  

Cognitive Neural Mechanism of Thinking Asymmetry of Yin and Yang Transformation in Traditional Chinese Medicine

作　　者：黄慧雯 吴彤 窦嘉乐 赖敏 韩布新[4] 贾春华 HUANG Huiwen;WU Tong;DOU Jiale;LAI Min;HAN Buxin;JIA Chunhua(School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China;School of Basic Medicine,Zhejiang Chinese Medical University,Hangzhou 310053,China;School of Basic Medical Sciences,Shaanxi University of Chinese Medicine,Xianyang 712046,China;Key Laboratory of Mental Health,Institute of Psychology of China Academy of Sciences,Beijing 100101,China)

机构地区：[1]北京中医药大学中医学院,北京100029 [2]浙江中医药大学基础医学院,杭州310053 [3]陕西中医药大学基础医学院,咸阳712046 [4]中国科学院心理研究所心理健康重点实验室,北京100101

出　　处：《世界中医药》2022年第23期3318-3324,共7页World Chinese Medicine

基　　金：国家自然科学基金项目(81874514)——基于事件相关电位与功能性磁共振成像技术的中医语言研究;国家自然科学基金项目(82074582)——中医五行推理的逻辑解析与ERP及fMRI的实证研究。

摘　　要：目的:利用事件相关电位(ERP)和功能性磁共振成像(fMRI)技术揭示阴阳转化思维不对称性及其认知神经机制。方法:采用ERP和fMRI技术分别记录30名中医学专业研究生完成一项医学阴阳转化的判断任务过程中的反应时、正确率、脑电波信号和血氧水平依赖信号,并进行统计分析。结果:中医研究生判断阳转阴的反应速度快于判断阴转阳。ERP结果表明阴阳转化在认知加工后期的不对称性,与阴转阳在注意资源分配、工作记忆过程、语义分析与情境整合中存在优势相关。fMRI结果发现右侧脑岛和右侧额中回对阴阳转化认知的响应方式存在不对称,提示情绪加工和奖赏机制可能对维持阴转阳任务的工作记忆密切相关。而额中回或参与消极信息的抑制反向促进阴转阳任务的语义整合分析。结论:阴阳转化存在认知加工不对称性,大脑右半球对阴阳转化认知转化存在不同的加工模式。Objective:To reveal the thinking asymmetry of yin and yang transformation and its cognitive neural mechanism using event related potential(ERP)and functional magnetic resonance imaging(fMRI).Methods:ERP and fMRI were used to record the response time,accuracy rate,EEG signal and blood-oxygen-level-dependent(BOLD)signal of 30 postgraduates of traditional Chinese medicine(TCM)in judging yin and yang transformation,and statistical analysis was performed.Results:The response speed of TCM postgraduates in judging yang to yin transformation was faster than that in judging yin to yang transformation.ERP results indicated that the asymmetry in later stage of cognitive processing of yin and yang transformation was related to the advantages in attention resource allocation of yin to yang transformation,working memory process,semantic analysis and situational integration.In fMRI experiment,the right insula and right middle frontal gyrus had asymmetric cognitive responses to yin to yang transformation,suggesting that emotional processing and reward mechanism might be closely related to maintaining the working memory of yin to yang transformation,while the middle frontal gyrus might participate in the inhibition of negative information to promote the semantic integration of yin to yang transformation.Conclusion:There is asymmetry in the cognitive processing of yin and yang transformation,and the right hemisphere of the brain has different cognitive processing modes of yin and yang transformation.

关 键 词：阴阳转化 事件相关电位 功能性磁共振成像 中医思维 工作记忆 脑岛 

分 类 号：R2-03[医药卫生—中医学]