血清补体及IL-25在SLE中的表达及临床意义  

Expression and clinical significance of serum complement and IL-25 in systemic lupus erythematosus

作　　者：王杨[1] 罗钰鸿 廖媛[1] Wang Yang;Luo Yuhong;Liao Yuan(Department of Laboratory Medicine,the Third Affiliated Hospital of Sun Yat-sen University,Guangzhou 510630,China)

机构地区：[1]中山大学附属第三医院检验科,广州510630

出　　处：《新医学》2022年第12期931-934,共4页Journal of New Medicine

摘　　要：目的探讨血清补体(C)及IL-25在SLE累及单个或多个器官系统时的表达差异,以及血清C3、C4、总补体(CH50)、IL-25、CRP、抗双链DNA(dsDNA)抗体之间的相关性。方法选择151例SLE患者,按SLE累及器官情况分为单纯SLE组(58例)、单器官损伤组(67例,其中狼疮性肾炎51例、血液系统损伤13例、其他器官损伤3例)和多器官损伤组(26例,其中狼疮性肾炎合并其他器官损伤25例,血液系统损伤合并脑损伤1例)。观察3组患者血清C3、C4、CH50、IL-25、CRP水平和抗dsDNA抗体阳性率间的差异,并分析各指标间的相关性。结果3组SLE患者血清C4、CH50、IL-25、CRP水平相近,组间血清C3水平和抗dsDNA抗体阳性率比较差异均有统计学意义(P均<0.05);与其他2组比较,多器官损伤组血清C3较低,抗dsDNA抗体阳性率较高(P均<0.017)。Spearman相关性分析显示,SLE患者的C3水平与C4(rs=0.73,P<0.001)、CH50(rs=0.81,P<0.01)水平呈正相关,而与IL-25呈负相关(rs=-0.14,P<0.001)。结论SLE患者发生多器官损伤时血清C3水平下降、抗dsDNA抗体阳性率升高,检测血清补体水平对SLE患者发生多器官损伤的预测有重要意义。Objective To determine the differences in the expression of serum complement(C)and IL-25 in systemic lupus erythematosus(SLE)involved with single or multi-organ systems,and analyze the correlation between serum C3,C4,CH50,IL-25,C-reactive protein(CRP)and anti-dsDNA antibody.Methods A total of 151 SLE patients were included in this study.According to the organ involvement status,all patients were divided into the SLE alone(n=58),SLE complicated with single organ injury(n=67,51 cases of lupus nephritis,13 cases of blood system injury and 3 cases of other organ injury),and SLE complicated with multiorgan injury groups(n=26,25 cases of lupus nephritis complicated with other organ injury and 1 blood system complicated with brain injury).The levels of serum C3,C4,CH50,IL-25 and CRP,and positive rate of anti-dsDNA antibody were detected among three groups.The correlation among these indexes was analyzed.Results There was no significant difference in the C4,CH50,IL-25 and CRP levels among three groups.There were significant differences in the C3 level and positive rate of anti-dsDNA antibody among three groups(all P<0.05).In the multi-organ injury group,C3 level was significantly lower,whereas positive rate of anti-dsDNA antibody was significantly higher compared with those in the remaining two groups(all P<0.017).Spearman rank correlation test indicated that C3 level was positively correlated with C4(r=0.73,P<0.001)and CH50 levels(r_(s)=0.81,P<0.01),whereas negatively correlated with IL-25 level(r_(s)=-0.14,P<0.001).Conclusions In SLE patients with multi-organ involvement,serum C3 level is significantly decreased,whereas positive rate of anti-dsDNA antibody is significantly increased.Detection of serum complement levels is of clinical significance for the prediction of multi-organ injury in SLE patients.

关 键 词：系统性红斑狼疮 多器官损伤 补体 白介素-25 C-反应蛋白 

分 类 号：R593.241[医药卫生—内科学]