王素梅治疗儿童抽动障碍处方用药规律及演变的多维度分析  

Multi-dimensional Analysis on Medication Law and Change ofWang Sumei for the Treatment of Tic Disorders in Children

作　　者：王静[1] 谷晓红[1] 骆长永 王振东 路晨 韩枝彤 郝宏文[2] 刘铁钢[1] 白辰[1] 吴力群[2] 王素梅(指导)[2] WANG Jing;GU Xiaohong;LUO Changyong;WANG Zhendong;LU Chen;HAN Zhitong;HAO Hongwen;LIU Tiegang;BAI Chen;WU Liqun(WANG Sumei21.Beijing University of Chinese Medicine,Beijing 100029,China;Dongfang Hospital Beijing University of Chinese Medicine,Beijing 100078,China)

机构地区：[1]北京中医药大学,北京100029 [2]北京中医药大学东方医院,北京100078

出　　处：《中国中医药信息杂志》2022年第12期46-51,共6页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家重点研发计划(2018YFC1704100、2018YFC1704101);国家中医药管理局中医药创新团队及人才支持计划(ZYYCXTD-C-202006);北京中医药大学重点攻关项目(2020-JYB-ZDGG-135)。

摘　　要：目的分析王素梅教授治疗儿童抽动障碍处方用药的规律及演变。方法选择2015年1月-2021年9月年王素梅教授诊治的儿童抽动障碍病例,采用R-Studio3.6.2、Mul-Charts1.8、Adobe Illustrator CC 2019分析患儿一般临床信息,多维度综合分析处方药物的性味归经及变化、药物群组,对高频药物进行流年变化分析,探讨王素梅教授治疗儿童抽动障碍的学术思想和处方用药规律及演变。结果共纳入处方13922首,涉及中药323种,中药总频次265300次。药性以温性为主,药味以辛味和甘味为主。药物归经主要为肝经、脾经等。稳定药物群组为防风、葛根、钩藤、石菖蒲、陈皮、谷精草、川芎、茯苓、法半夏、伸筋草、白芍、太子参、麸炒白术、木瓜、山药。近2年核心药物为防风、葛根、钩藤、伸筋草、石菖蒲、谷精草、炒僵蚕。时间-药物归经变化趋势分析、流年分析及核心药物分析显示,防风、葛根、钩藤、石菖蒲、陈皮、谷精草、川芎等以息风止痉化痰为主的药物占比持续较高;茯苓、麸炒白术、山药等脾经药物随时间推移占比逐渐减少,天麻、炒僵蚕、北柴胡等肝经药物占比逐渐升高。结论王素梅教授治疗儿童抽动障碍以息风止痉化痰立法,以肝、脾为中心,近年来更加重视从肝论治。Objective To analysis the medication law and change of Wang Sumei in the treatment of tic disorders(TD)in children.Methods The cases of children with TD diagnosed and treated by Professor Wang Sumei from January 2015 to September 2021 were selected.R-Studio 3.6.2,Mul-Charts 1.8,and Adobe Illustrator CC 2019 were used to analyze the clinical information of children with TD.Through the multi-dimensional analysis on the property,taste and meridian tropism,herbal groups,and the changes of high-frequency medicine over the year were also analyzed,in order to summarize Professor Wang’s,academic thoughts on the treatment of TD and the medication law and change of prescriptions for TD in children.Results Totally 13922 prescriptions were included,involving 323 kinds of Chinese materia medica,with a total frequency of 265300 times.The main medicinal property was warm,and the main medicinal tastes were pungent and sweet.The main meridians of drugs were liver meridian and spleen meridian.The stable medicinal group was composed of Saposheikovize Radix,Puerariae Lobatue Radix,Uncariae Ramulus cum Uncis,Acori Tatarinowii Rhizoma,Citri Reticulatae Pericarpium,Eriocauli Flos,Chuanxiong Rhizoma,Poria,Pinelliae Rhizoma Praeparatum,Herba Lycopodii,Paeoniae Radix Alba,Pseudostellariae Radix,fried Atractylodis Macrocephalae Rhizoma,Chaenomelis Fructus,Dioscoreae Rhizoma.The core medicines were Saposheikovize Radix,Puerariae Lobatue Radix,Uncariae Ramulus cum Uncis,Herba Lycopodii,Acori Tatarinowii Rhizoma,Eriocauli Flos,and fried Bombyx Batryticatus for the past two years.Time-drug analysis on the evolution trend of meridian tropism,fleeting year analysis and core drug analysis showed that the proportion of medicines mainly used for relieving wind,relieving spasm and resolving phlegm continued to be relatively high,such as Saposheikovize Radix,Puerariae Lobatue Radix,Uncariae Ramulus cum Uncis,Acori Tatarinowii Rhizoma,Citri Reticulatae Pericarpium,Eriocauli Flos,and Chuanxiong Rhizoma.Poria,fried Atractylodis Macrocephalae Rhizoma,D

关 键 词：儿童抽动障碍 多维度分析 用药规律 流年分析 

分 类 号：R2-05[医药卫生—中医学] R272.974