弥漫性毒性甲状腺肿患者血清高半胱氨酸蛋白61及Fractalkine水平的表达及其临床意义  

Expression of Serum Cysteine Rich 61 and Fractalkine in Patients with Graves'Disease and its Clinical Significance

作　　者：杜娟 卢晓丽[1] 张雪 王占龙[2] 周晓红[1] 李玥 夏斌 DU Juan;LU Xiao-li;ZHANG Xue;WANG Zhan-long;ZHOU Xiao-hong;LI Yue;XIA Bin(The Fourth Department of General Surgery,Handan Central Hospital of Hebei Province,Handan,Hebei,056001,China;Department of Otolaryngology Head and Neck Surgery,the Fourth Hospital of Hebei Medical University,Shijiazhuang,Hebei,050000,China;Department of Blood Transfusion,Hanzhong People's Hospital of Shanxi Province,Hanzhong,Shaanxi,723000,China)

机构地区：[1]河北省邯郸市中心医院普外四科,河北邯郸056001 [2]河北医科大学第四医院耳鼻喉头颈外科,河北石家庄050000 [3]陕西省汉中市人民医院输血科,陕西汉中723000

出　　处：《现代生物医学进展》2022年第20期3987-3990,共4页Progress in Modern Biomedicine

基　　金：河北省医学科学研究课题计划项目(20181672)。

摘　　要：目的:探讨弥漫性毒性甲状腺肿(GD)患者血清高半胱氨酸蛋白61(CYR61)、Fractalkine水平的表达及其临床意义。方法:选取2018年3月~2021年10月河北省邯郸市中心医院收治的57例GD患者作为研究组。另取同期健康体检者50例。采集所有受试者的静脉血,检测血清CYR61、Fractalkine水平,甲状腺功能及甲状腺自身抗体相关指标。采用Pearson检验分析GD患者血清CYR61、Fractalkine水平与甲状腺功能及甲状腺自身抗体相关指标的相关性。结果:研究组血清CYR61、Fractalkine水平均高于对照组,差异均有统计学意义(均P<0.05)。研究组血清游离三碘甲腺原氨酸(FT3)、游离四碘甲腺原氨酸(FT4)均高于对照组,而促甲状腺激素(TSH)水平低于对照组,差异均有统计学意义(均P<0.05)。研究组抗甲状腺球蛋白抗体(TGAb)、甲状腺过氧化物酶抗体(TPOAb)及促甲状腺激素受体抗体(TRAb)水平均高于对照组,差异均有统计学意义(均P<0.05)。经Pearson相关性分析发现,GD患者血清CYR61、Fractalkine水平与FT3、FT4、TGAb、TPOAb、TRAb水平均呈正相关,而与血清TSH水平呈负相关(均P<0.05)。结论:GD患者血清CYR61、Fractalkine水平异常高表达,且与患者甲状腺功能及甲状腺自身抗体有关。Objective:To investigate the expression and clinical significance of serum cysteine rich 61(CYR61)and Fractalkine in patients with Graves'Disease(GD).Methods:A total of 57 GD patients admitted to Handan Central Hospital of Hebei Province from March 2018 to October 2021 were selected as the research group.Another 50 healthy subjects were selected during the same period.Venous blood was collected from all subjects to detect serum CYR61,Fractalkine levels,thyroid function and thyroid autoantibody related indicators.Pearson test was used to analyze the correlation of serum CYR61 and Fractalkine levels with thyroid function and thyroid autoantibody related indicators in GD patients.Results:The serum CYR61 and Fractalkine levels in the study group were higher than those in the control group,and the differences were statistically significant(all P<0.05).Serum free triiodothyronine 3(FT3)and free tetriodothyronine 4(FT4)in the study group were higher than those in the control group,while the thyroid stimulating hormone(TSH)level was lower than that in the control group,the differences were statistically significant(all P<0.05).The anti-thyroglobulin antibody(TGAb),thyroid peroxidase antibody(TPOAb)and thyroid stimulating hormone receptor antibody(TRAb)levels in the study group were higher than those in the control group,and the differences were statistically significant(all P<0.05).Pearson correlation analysis showed that serum CYR61 and Fractalkine levels were positively correlated with the FT3,FT4,TGAb,TPOAb and TRAb levels in patients with GD,while negatively correlated with the serum TSH level(all P<0.05).Conclusions:Serum CYR61 and Fractalkine levels are abnormally high in patients with GD,which are related to thyroid function and thyroid autoantibodies.

关 键 词：弥漫性毒性甲状腺肿 CYR61 FRACTALKINE 甲状腺功能 甲状腺自身抗体 相关性 

分 类 号：R581.3[医药卫生—内分泌]