增强CT扫描中低渗造影剂碘海醇与碘克沙醇的有效性及安全性研究  

Study on the Efficacy and Safety of Iohexol and Iodixanol in Enhanced CT Scan

作　　者：郭志辉 张杰[1] GUO Zhihui;ZHANG Jie(Department of Medical Imaging,Huaihe Hospital,Henan University,Kaifeng 475000,Henan,China)

机构地区：[1]河南大学淮河医院医学影像科,河南开封475000

出　　处：《中国药物滥用防治杂志》2022年第10期1470-1472,1481,共4页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:探讨增强CT扫描检查中碘海醇与碘克沙醇两种低渗造影剂的临床应用效果及安全性。方法:回顾性分析2020年3月—2022年5月我院放射科收治的73例行增强CT扫描的患者作为研究对象,根据患者所选用造影剂的不同将患者分为A组(n=38)和B组(n=35)。A组予以碘海醇,B组予以碘克沙醇,比较两组造影效果、肾功能及不良反应发生率。结果:A组造影优良率为92.11%,与B组的97.14%比较,差异无统计学意义(P>0.05)。造影后,B组BUN、UAER和Scr低于A组,差异有统计学意义(P<0.05)。B组不良反应发生率为2.86%,低于A组的15.79%,差异有统计学意义(P<0.05)。结论:在增强CT扫描中碘克沙醇和碘海醇两种低渗造影剂均能取得理想的造影效果,而碘克沙醇在安全性方面更具优势。Objective: To investigate the clinical application effect and safety of iohexol and iodixanol in enhanced CT scan.Methods: A retrospective analysis of 73 patients who underwent enhanced CT scan in the radiology department of our hospital from March 2020 to May 2022 was conducted. According to the different contrast agents selected by the patients, the patients were divided into group A(n=38) and group B(n=35). Group A was given iohexol, and group B was given iodixanol. The contrast effect, renal function and incidence of adverse reactions were compared between the two groups. Results:The excellent and good rate of angiography in group A was 92.11%, compared with 97.14% in group B, the difference was not statistically significant(P>0.05). After angiography, BUN, UAER and Scr in group B were lower than those in group A(P<0.05). The incidence of adverse reactions in group B was 2.86%, which was lower than 15.79% in group A, the difference was statistically significant(P<0.05). Conclusion: Both iodixanol and iohexol can achieve ideal contrast effect in enhanced CT scan, and iodixanol has more advantages in safety.

关 键 词：增强CT 碘克沙醇 碘海醇 肾毒性 

分 类 号：R981[医药卫生—药品]