盐酸拉贝洛尔片治疗子痫前期的疗效研究  

Effect of Labetalol Hydrochloride Tablets in Treatment of Preeclampsia

作　　者：陆敏[1] 朱丹婴 LU Min;ZHU Danying(Department of Obstetrics and Gynecology,Changshu Hospital of Traditional Chinese Medicine(New District Hospital),Changshu 215500,Jiangsu,China)

机构地区：[1]常熟市中医院(新区医院)妇产科,江苏常熟215500

出　　处：《中国药物滥用防治杂志》2022年第10期1473-1477,共5页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:探讨盐酸拉贝洛尔片治疗子痫前期的疗效及对内皮细胞功能的影响。方法:选取2020年1月—2021年6月于我院产检的80例子痫前期高危产妇作为研究对象,根据随机数字表法将其分为观察组和对照组,每组40例。对照组接受常规产检直至分娩完成,观察组于妊娠20—24周给予产妇盐酸拉贝洛尔片治疗,比较两组产妇结局、新生儿结局、内皮细胞功能,以及舒张压、收缩压指标、24 h蛋白尿水平、不良反应。结果:观察组产妇子痫前期发病时间晚于对照组(P<0.05),而观察组与对照组胸腹水发病率、胎盘早剥发病率比较,差异无统计学意义(P>0.05);观察组新生儿分娩体重重于对照组、分娩孕周大于对照组(P<0.05),而观察组与对照组新生儿窒息发生率、早产儿发生率以及5min Apgar评分比较,差异无统计学意义(P>0.05);观察组治疗后NO水平高于对照组、ET-1水平低于对照组(P<0.05);观察组治疗后舒张压、收缩压指标以及24 h蛋白尿水平均低于对照组(P<0.05);观察组不良反应发生率与对照组比较,差异无统计学意义(P>0.05)。结论:盐酸拉贝洛尔片治疗可改善子痫前期产妇结局、新生儿结局及内皮细胞功能,控制血压水平,降低24 h蛋白尿水平,且安全性较高。Objective: To investigate the efficacy of labetalol hydrochloride tablets in the treatment of preeclampsia and its effect on endothelial cell function. Methods: A total of 80 high-risk pregnant women with preeclampsia who underwent antenatal examination in our hospital from January 2020 to June 2021 were selected as study subjects. According to the random number table method, they were divided into observation group and control group, with 40 cases in each group. The control group received routine prenatal examination until delivery was completed. The observation group was treated with labetalol hydrochloride tablets at 20-24 weeks of pregnancy. The maternal outcomes, neonatal outcomes, endothelial cell function and diastolic blood pressure, systolic blood pressure index, 24 h proteinuria level and adverse reactions were compared between the two groups. Results: The onset time of preeclampsia in the observation group was later than that in the control group(P<0.05), and there was no significant difference in the incidence of hydrothorax and placenta abruption between the observation group and the control group(P>0.05). The neonatal delivery weight and gestational age of the observation group were heavier than those of the control group(P<0.05), while there were no significant differences in the incidence of neonatal asphyxia, preterm infants and 5-minute Apgar score between the observation group and the control group(P>0.05). After treatment, the level of NO in the observation group was higher than that in the control group, and the level of ET-1 was lower than that in the control group(P<0.05). After treatment, diastolic blood pressure, systolic blood pressure and 24 h proteinuria in the observation group were lower than those in the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05). Conclusion: Labeolol hydrochloride tablets can improve the maternal outcome and neonatal outcome of preeclampsia, improve end

关 键 词：盐酸拉贝洛尔 子痫前期 内皮细胞功能 24h蛋白尿水平 

分 类 号：R714.244[医药卫生—妇产科学]